Recombinant Human Friend leukemia integration 1 transcription factor (FLI1), Homo sapiens (Human), E.coli, N-terminal 10xHis-tagged, 57.0kDa, purity >85% as determined by SDS-PAGE.

Recombinant Human Friend leukemia integration 1 transcription factor (FLI1)

Recombinant Human Friend leukemia integration 1 transcription factor (FLI1) — Sequence-specific transcriptional activator. Purity >85%.

SKU: BCRECP-000678 Category:
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Product Specifications

Product SkuBCRECP-000678
Product DescriptionRecombinant Human Friend leukemia integration 1 transcription factor (FLI1) Protein is expressed from E.coli with N-terminal 10xHis-tagged. It contains 1-452aa. [Accession | Q01543].
Uniprot No.Q01543
Gene NamesFLI1
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region1-452aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 10xHis-tagged
Molecular weight57.0kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasCancer

Function

Sequence-specific transcriptional activator. Recognizes the DNA sequence 5'-C[CA]GGAAGT-3'.

Biological Context

Subcellular Location: Nucleus
Disease Association: Ewing sarcoma (ES) : A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors. [The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration involving FLI1 is found in patients with Erwing sarcoma. Translocation t(11;22)(q24;q12) with EWSR1] | Bleeding disorder, platelet-type, 21 (BDPLT21) : A disorder characterized by increased bleeding tendency due to platelet dysfunction. Clinical features include epistaxis, hematomas, bleeding after tooth extraction, and menorrhagia. BDPLT21 patients may have mild to moderate thrombocytopenia. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Friend leukemia integration 1 transcription factor (FLI1) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 1-452aa, with N-terminal 10xHis-tagged tag, molecular weight 57.0kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Sequence-specific transcriptional activator (PubMed:24100448, PubMed:26316623, PubMed:28255014). Recognizes the DNA sequence 5'-C[CA]GGAAGT-3'

Subcellular Location

Nucleus

Disease Association

Ewing sarcoma (ES) : A highly malignant, metastatic, primitive small round cell tumor of bone and soft tissue that affects children and adolescents. It belongs to the Ewing sarcoma family of tumors, a group of morphologically heterogeneous neoplasms that share the same cytogenetic features. They are considered neural tumors derived from cells of the neural crest. Ewing sarcoma represents the less differentiated form of the tumors. [The gene represented in this entry is involved in disease pathogenesis. A chromosomal aberration involving FLI1 is found in patients with Erwing sarcoma. Translocation t(11;22)(q24;q12) with EWSR1] | Bleeding disorder, platelet-type, 21 (BDPLT21) : A disorder characterized by increased bleeding tendency due to platelet dysfunction. Clinical features include epistaxis, hematomas, bleeding after tooth extraction, and menorrhagia. BDPLT21 patients may have mild to moderate thrombocytopenia. [The disease is caused by variants affecting the gene represented in this entry]

Subunit

Can form homodimers or heterodimers with ETV6/TEL1

Gene: FLI1  |  Organism: Homo sapiens  |  Synonyms: Proto-oncogene Fli-1; Transcription factor ERGB
Key Publications

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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