Recombinant Human G protein-activated inward rectifier potassium channel 1 (KCNJ3)(F137S) Protein, Homo sapiens (Human), in vitro E.coli expression system, N-terminal 10xHis-tagged, 62.6kDa, purity >85% as determined by SDS-PAGE.

Recombinant Human G protein-activated inward rectifier potassium channel 1 (KCNJ3)(F137S) Protein

Recombinant Human G protein-activated inward rectifier potassium channel 1 (KCNJ3)(F137S) Protein — Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Purity >85%.

SKU: BCRECP-00366TM Category:
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Product Specifications

Uniprot No.P48549
Gene NamesKCNJ3
PurityGreater than 85% as determined by SDS-PAGE.
Expression Systemin vitro E.coli expression system
Expression Region1-501aa(F137S)
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 10xHis-tagged
Molecular weight62.6kDa
ActivityNot Test
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Function

Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium.

Biological Context

Subcellular Location: Membrane (Multi-pass membrane protein)

Product Specifications

Recombinant Human G protein-activated inward rectifier potassium channel 1 (KCNJ3)(F137S) Protein is a recombinant protein from Homo sapiens (Human), expressed in in vitro E.coli expression system, covering amino acids 1-501aa(F137S), with N-terminal 10xHis-tagged tag, molecular weight 62.6kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Not Test

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This potassium channel is controlled by G proteins (PubMed:8804710, PubMed:8868049). This receptor plays a crucial role in regulating the heartbeat (By similarity)

Subcellular Location

Membrane (Multi-pass membrane protein)

Subunit

Associates with KCNJ5/GIRK4 or KCNJ6/GIRK2 to form a G protein activated heteromultimer pore-forming unit. The resulting inward current is much larger (PubMed:10659995, PubMed:8868049). Associates with KCNJ9/GIRK3 to form a G protein activated heteromultimer pore-forming unit (By similarity)

Gene: KCNJ3  |  Organism: Homo sapiens  |  Synonyms: Inward rectifier K(+) channel Kir3.1; Potassium channel, inwardly rectifying subfamily J member 3
Key Publications

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Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

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Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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