Function
Receptor for lysophosphatidic acid (LPA). Necessary for p53/TP53-dependent survival in response to DNA damage. Promotes the Hippo-YAP signaling pathway and thereby modulates glycolysis and oxidative stress production by the regulation of hexokinase-2/HK2.
Biological Context
Subcellular Location: Cell membrane (Multi-pass membrane protein)
Tissue Specificity: Expressed in placenta and prostate. Weaker expression in thymus. Not expressed in thalamus, hippocampus, pons or cerebellum. Overexpressed in squamous cell carcinoma of the lung
Product Specifications
Recombinant Human G-protein coupled receptor 87 (GPR87) Protein is a recombinant protein from Homo sapiens (Human), expressed in in vitro E.coli expression system, covering amino acids 1-358aa, with C-terminal Twin-Strep-tagged tag, molecular weight 44.5kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.
