Recombinant Human G2/mitotic-specific cyclin-B1 (CCNB1), Homo sapiens (Human), E.coli, N-terminal 6xHis-tagged, 52.4kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human G2/mitotic-specific cyclin-B1 (CCNB1)

Recombinant Human G2/mitotic-specific cyclin-B1 (CCNB1) — Essential for the control of the cell cycle at the G2/M (mitosis) transition. Purity >90%.

SKU: BCRECP-000257 Category:
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Product Specifications

Product SkuBCRECP-000257
Product DescriptionRecombinant Human G2/mitotic-specific cyclin-B1 (CCNB1) Protein is expressed from E.coli with N-terminal 6xHis-tagged. It contains 1-433aa. [Accession | P14635].
Uniprot No.P14635
Gene NamesCCNB1
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region1-433aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-tagged
Molecular weight52.4kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasCell Biology

Function

Essential for the control of the cell cycle at the G2/M (mitosis) transition. Binds and activates cyclin-dependent protein kinase CDK1/CDC2.

Biological Context

Subcellular Location: Cytoplasm; Nucleus; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome

Product Specifications

Recombinant Human G2/mitotic-specific cyclin-B1 (CCNB1) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 1-433aa, with N-terminal 6xHis-tagged tag, molecular weight 52.4kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Essential for the control of the cell cycle at the G2/M (mitosis) transition (PubMed:27030811, PubMed:17495531, PubMed:17495533). Binds and activates cyclin-dependent protein kinase CDK1/CDC2 (PubMed:41100585)

Subcellular Location

Cytoplasm; Nucleus; Cytoplasm, cytoskeleton, microtubule organizing center, centrosome

Subunit

Interacts with the CDK1/CDC2 protein kinase to form a serine/threonine kinase holoenzyme complex known as maturation promoting factor (MPF) (PubMed:41100585). The cyclin subunit imparts substrate specificity to the complex. Binds HEI10. Interacts with catalytically active RALBP1 and CDK1/CDC2 during mitosis to form an endocytotic complex during interphase. Interacts with CCNF; interaction is required for nuclear localization. Interacts with CDK5RAP3 (PubMed:15790566). Interacts with RFPL4A and UBE2A (By similarity). Interacts with INCA1 (PubMed:21540187)

Gene: CCNB1  |  Organism: Homo sapiens
Key Publications

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How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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