Recombinant Human Gamma-aminobutyric acid receptor-associated protein (GABARAP), Homo sapiens (Human), Yeast, C-terminal 6xHis-tagged, 15.3kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Gamma-aminobutyric acid receptor-associated protein (GABARAP)

Recombinant Human Gamma-aminobutyric acid receptor-associated protein (GABARAP) — Ubiquitin-like modifier that plays a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Purity >90%.

SKU: BCRECP-000715 Category:
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Product Specifications

Product SkuBCRECP-000715
Product DescriptionRecombinant Human Gamma-aminobutyric acid receptor-associated protein (GABARAP) Protein is expressed from Yeast with C-terminal 6xHis-tagged. It contains 1-116aa. [Accession | O95166].
Uniprot No.O95166
Gene NamesGABARAP
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemYeast
Expression Region1-116aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal 6xHis-tagged
Molecular weight15.3kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasTransport

Function

Ubiquitin-like modifier that plays a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton. Involved in autophagy: while LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation. Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover.

Biological Context

Subcellular Location: Cytoplasmic vesicle, autophagosome membrane; Endomembrane system; Cytoplasm, cytoskeleton; Golgi apparatus membrane; Cytoplasmic vesicle
Tissue Specificity: Heart, brain, placenta, liver, skeletal muscle, kidney and pancreas

Product Specifications

Recombinant Human Gamma-aminobutyric acid receptor-associated protein (GABARAP) is a recombinant protein from Homo sapiens (Human), expressed in Yeast, covering amino acids 1-116aa, with C-terminal 6xHis-tagged tag, molecular weight 15.3kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Ubiquitin-like modifier that plays a role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton (PubMed:9892355). Involved in autophagy: while LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (PubMed:15169837, PubMed:20562859, PubMed:22948227). Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover (PubMed:31006538). Also required for the local activation of the CUL3(KBTBD6/7) E3 ubiquitin ligase complex, regulating ubiquitination and degradation of TIAM1, a guanyl-nucleotide exchange factor (GEF) that activates RAC1 and downstream signal transduction (PubMed:25684205). Thereby, regulates different biological processes including the organization of the cytoskeleton, cell migration and proliferation (PubMed:25684205). Involved in apoptosis (PubMed:15977068). Participates in selective ER-phagy through interaction with UBAC2, promoting recruitment of UBAC2-associated ER fragments to autophagosomes (PubMed:39284914)

Subcellular Location

Cytoplasmic vesicle, autophagosome membrane; Endomembrane system; Cytoplasm, cytoskeleton; Golgi apparatus membrane; Cytoplasmic vesicle

Tissue Specificity

Heart, brain, placenta, liver, skeletal muscle, kidney and pancreas

Subunit

Interacts with GPHN and NSF (By similarity). Interacts with ATG7, ATG13 (PubMed:11096062, PubMed:12507496, PubMed:23043107). Interacts with ATG3 (PubMed:11825910, PubMed:12507496, PubMed:37252361). Interacts with alpha- and beta-tubulin (PubMed:11729197, PubMed:9892355). Interacts with GABRG2 (PubMed:11729197, PubMed:9892355). Interacts with RB1CC1 (PubMed:23043107). Interacts with ULK1 (PubMed:11146101, PubMed:23043107). Interacts with CALR (PubMed:19154346). Interacts with DDX47 (PubMed:15977068). Interacts with TP53INP1 and TP53INP2 (PubMed:19056683, PubMed:22421968, PubMed:22470510). Interacts with TBC1D5 and TBC1D25 (PubMed:21383079, PubMed:22354992). Directly interacts with SQSTM1 (PubMed:17580304, PubMed:24668264). Interacts with MAPK15 (PubMed:22948227). Interacts with TECPR2 (PubMed:20562859). Interacts with PCM1 (PubMed:24089205). Interacts with TRIM5 and TRIM21 (PubMed:25127057, PubMed:26347139). Interacts with MEFV (PubMed:26347139). Interacts with KIF21B (By similarity). Interacts with WDFY3; this interaction is required for WDFY3 recruitment to MAP1LC3B-positive p62/SQSTM1 bodies (PubMed:24668264). Interacts with the reticulophagy receptor TEX264 (PubMed:31006538). Interacts with UBA5 (PubMed:26929408). Interacts with FLCN; interaction regulates autophagy (PubMed:25126726). Interacts with KBTBD6 and KBTBD7; the interaction is direct and required for the ubiquitination of TIAM1 (PubMed:25684205). Interacts with reticulophagy regulators RETREG1, RETREG2 and RETREG3 (PubMed:34338405). Interacts with IRGM (PubMed:29420192). Interacts with STX17 (PubMed:29420192). Interacts with CT55; this interaction may be important for GABARAP protein stability (PubMed:36481789). Interacts with DNM2 (PubMed:32315611). Interacts with NCOA4 (via C-terminus) (By similarity). Interacts with the 'Ser-223' phosphorylated form of UBAC2 (via the LIR motif) (PubMed:39284914)

Gene: GABARAP  |  Organism: Homo sapiens  |  Synonyms: GABA(A) receptor-associated protein; MM46
Key Publications

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