Recombinant Human Gamma-aminobutyric acid receptor-associated protein-like 1 (GABARAPL1), Homo sapiens (Human), E.coli, N-terminal GST-tagged, 40.9kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Gamma-aminobutyric acid receptor-associated protein-like 1 (GABARAPL1)

Recombinant Human Gamma-aminobutyric acid receptor-associated protein-like 1 (GABARAPL1) — Ubiquitin-like modifier that increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Purity >90%.

SKU: BCRECP-000716 Category:
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Product Specifications

Product SkuBCRECP-000716
Product DescriptionRecombinant Human Gamma-aminobutyric acid receptor-associated protein-like 1 (GABARAPL1) Protein is expressed from E.coli with N-terminal GST-tagged. It contains 1-117aa. [Accession | Q9H0R8].
Uniprot No.Q9H0R8
Gene NamesGABARAPL1
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region1-117aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal GST-tagged
Molecular weight40.9kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasNeuroscience

Function

Ubiquitin-like modifier that increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles. While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.

Biological Context

Subcellular Location: Cytoplasmic vesicle, autophagosome; Cytoplasmic vesicle membrane (Lipid-anchor); Cytoplasm, cytoskeleton; Endoplasmic reticulum; Golgi apparatus
Tissue Specificity: Ubiquitous. Expressed at very high levels in the brain, heart, peripheral blood leukocytes, liver, kidney, placenta and skeletal muscle. Expressed at very low levels in thymus and small intestine. In the brain, expression is particularly intense in motoneurons in the embryo and in neurons involved in somatomotor and neuroendocrine functions in the adult, particularly in the substantia nigra pars compacta

Product Specifications

Recombinant Human Gamma-aminobutyric acid receptor-associated protein-like 1 (GABARAPL1) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 1-117aa, with N-terminal GST-tagged tag, molecular weight 40.9kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Ubiquitin-like modifier that increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor (PubMed:16431922). Involved in formation of autophagosomal vacuoles (PubMed:20404487). While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (PubMed:20404487). Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover (PubMed:31006537, PubMed:31006538)

Subcellular Location

Cytoplasmic vesicle, autophagosome; Cytoplasmic vesicle membrane (Lipid-anchor); Cytoplasm, cytoskeleton; Endoplasmic reticulum; Golgi apparatus

Tissue Specificity

Ubiquitous. Expressed at very high levels in the brain, heart, peripheral blood leukocytes, liver, kidney, placenta and skeletal muscle. Expressed at very low levels in thymus and small intestine. In the brain, expression is particularly intense in motoneurons in the embryo and in neurons involved in somatomotor and neuroendocrine functions in the adult, particularly in the substantia nigra pars compacta

Subunit

(Microbial infection) Interacts with Kaposi's sarcoma-associated herpesvirus protein VIRF-1

Gene: GABARAPL1  |  Organism: Homo sapiens  |  Synonyms: Early estrogen-regulated protein; GABA(A) receptor-associated protein-like 1; Glandular epithelial cell protein 1
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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