Recombinant Human Gamma-aminobutyric acid receptor-associated protein-like 1 (GABARAPL1), Homo sapiens (Human), E.coli, N-terminal GST-tagged, 40.9kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Gamma-aminobutyric acid receptor-associated protein-like 1 (GABARAPL1)

Recombinant Human Gamma-aminobutyric acid receptor-associated protein-like 1 (GABARAPL1) — Ubiquitin-like modifier that increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Purity >90%.

SKU: BCRECP-000716 Category:
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Product Specifications

Product SkuBCRECP-000716
Product DescriptionRecombinant Human Gamma-aminobutyric acid receptor-associated protein-like 1 (GABARAPL1) Protein is expressed from E.coli with N-terminal GST-tagged. It contains 1-117aa. [Accession | Q9H0R8].
Uniprot No.Q9H0R8
Gene NamesGABARAPL1
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region1-117aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal GST-tagged
Molecular weight40.9kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasNeuroscience

Function

Ubiquitin-like modifier that increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor. Involved in formation of autophagosomal vacuoles. While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation.

Biological Context

Subcellular Location: Cytoplasmic vesicle, autophagosome; Cytoplasmic vesicle membrane (Lipid-anchor); Cytoplasm, cytoskeleton; Endoplasmic reticulum; Golgi apparatus
Tissue Specificity: Ubiquitous. Expressed at very high levels in the brain, heart, peripheral blood leukocytes, liver, kidney, placenta and skeletal muscle. Expressed at very low levels in thymus and small intestine. In the brain, expression is particularly intense in motoneurons in the embryo and in neurons involved in somatomotor and neuroendocrine functions in the adult, particularly in the substantia nigra pars compacta

Product Specifications

Recombinant Human Gamma-aminobutyric acid receptor-associated protein-like 1 (GABARAPL1) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 1-117aa, with N-terminal GST-tagged tag, molecular weight 40.9kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Ubiquitin-like modifier that increases cell-surface expression of kappa-type opioid receptor through facilitating anterograde intracellular trafficking of the receptor (PubMed:16431922). Involved in formation of autophagosomal vacuoles (PubMed:20404487). While LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (PubMed:20404487). Through its interaction with the reticulophagy receptor TEX264, participates in the remodeling of subdomains of the endoplasmic reticulum into autophagosomes upon nutrient stress, which then fuse with lysosomes for endoplasmic reticulum turnover (PubMed:31006537, PubMed:31006538)

Subcellular Location

Cytoplasmic vesicle, autophagosome; Cytoplasmic vesicle membrane (Lipid-anchor); Cytoplasm, cytoskeleton; Endoplasmic reticulum; Golgi apparatus

Tissue Specificity

Ubiquitous. Expressed at very high levels in the brain, heart, peripheral blood leukocytes, liver, kidney, placenta and skeletal muscle. Expressed at very low levels in thymus and small intestine. In the brain, expression is particularly intense in motoneurons in the embryo and in neurons involved in somatomotor and neuroendocrine functions in the adult, particularly in the substantia nigra pars compacta

Subunit

(Microbial infection) Interacts with Kaposi's sarcoma-associated herpesvirus protein VIRF-1

Gene: GABARAPL1  |  Organism: Homo sapiens  |  Synonyms: Early estrogen-regulated protein; GABA(A) receptor-associated protein-like 1; Glandular epithelial cell protein 1
Key Publications

Explore closely related product collections, technology platforms, and custom production resources.

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How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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