Recombinant Human Gamma-aminobutyric acid receptor-associated protein-like 2 (GABARAPL2), Homo sapiens (Human), Yeast, C-terminal 6xHis-tagged, 15.2kDa, purity >95% as determined by SDS-PAGE.

Recombinant Human Gamma-aminobutyric acid receptor-associated protein-like 2 (GABARAPL2)

Recombinant Human Gamma-aminobutyric acid receptor-associated protein-like 2 (GABARAPL2) — Ubiquitin-like modifier involved in intra-Golgi traffic. Purity >95%.

SKU: BCRECP-000719 Category:
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Product Specifications

Product SkuBCRECP-000719
Product DescriptionRecombinant Human Gamma-aminobutyric acid receptor-associated protein-like 2 (GABARAPL2) Protein is expressed from Yeast with C-terminal 6xHis-tagged. It contains 1-117aa. [Accession | P60520].
Uniprot No.P60520
Gene NamesGABARAPL2
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemYeast
Expression Region1-117aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal 6xHis-tagged
Molecular weight15.2kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasCancer

Function

Ubiquitin-like modifier involved in intra-Golgi traffic. Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation. It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1.

Biological Context

Subcellular Location: Cytoplasmic vesicle, autophagosome; Endoplasmic reticulum membrane; Golgi apparatus
Tissue Specificity: Ubiquitous. Expressed at high levels in the brain, heart, prostate, ovary, spleen and skeletal muscle. Expressed at very low levels in lung, thymus and small intestine

Product Specifications

Recombinant Human Gamma-aminobutyric acid receptor-associated protein-like 2 (GABARAPL2) is a recombinant protein from Homo sapiens (Human), expressed in Yeast, covering amino acids 1-117aa, with C-terminal 6xHis-tagged tag, molecular weight 15.2kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Ubiquitin-like modifier involved in intra-Golgi traffic (By similarity). Modulates intra-Golgi transport through coupling between NSF activity and SNAREs activation (By similarity). It first stimulates the ATPase activity of NSF which in turn stimulates the association with GOSR1 (By similarity). Involved in autophagy (PubMed:20418806, PubMed:23209295). Plays a role in mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production (PubMed:20418806, PubMed:23209295). Whereas LC3s are involved in elongation of the phagophore membrane, the GABARAP/GATE-16 subfamily is essential for a later stage in autophagosome maturation (PubMed:20418806, PubMed:23209295)

Subcellular Location

Cytoplasmic vesicle, autophagosome; Endoplasmic reticulum membrane; Golgi apparatus

Tissue Specificity

Ubiquitous. Expressed at high levels in the brain, heart, prostate, ovary, spleen and skeletal muscle. Expressed at very low levels in lung, thymus and small intestine

Subunit

Monomer. Interacts with ATG3, ATG7, ATG13 and ULK1 (PubMed:11096062, PubMed:11146101, PubMed:11825910, PubMed:12507496, PubMed:23043107). Interacts with TP53INP1 and TP53INP2 (PubMed:19056683, PubMed:22421968, PubMed:22470510). Interacts with TBC1D25 (PubMed:21383079). Directly interacts with SQSTM1 and BNIP3 (PubMed:17580304, PubMed:23209295). Interacts with TECPR2 and PCM1 (PubMed:20562859, PubMed:24089205). Interacts with TBC1D5 (PubMed:22354992). Interacts with TRIM5 (PubMed:25127057). Interacts with MEFV and TRIM21 (PubMed:26347139). Interacts with WDFY3 (PubMed:24668264). Interacts with UBA5; promoting recruitment of UBA5 to the endoplasmic reticulum membrane (PubMed:26929408, PubMed:30990354). Interacts with GOSR1 (By similarity). Interacts with KBTBD6 and KBTBD7; the interaction is direct (PubMed:25684205). Interacts with reticulophagy regulators RETREG1, RETREG2 and RETREG3 (PubMed:34338405). Interacts with IRGM (PubMed:29420192). Interacts with DNM2 (PubMed:32315611). Interacts with NCOA4 (By similarity). Interacts with IRGQ (PubMed:39481378)

Gene: GABARAPL2  |  Organism: Homo sapiens  |  Synonyms: GABA(A) receptor-associated protein-like 2; Ganglioside expression factor 2; General protein transport factor p16; Golgi-associated ATPase enhancer of 16 kDa; MAP1 light chain 3-related protein
Key Publications

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How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

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Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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