Recombinant Human Glycerol-3-phosphate dehydrogenase 1-like protein (GPD1L) (Active), Homo sapiens (Human), E.coli, N-terminal GST-tagged, 65.4 kDa, purity >85% as determined by SDS-PAGE.
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Recombinant Human Glycerol-3-phosphate dehydrogenase 1-like protein (GPD1L) (Active)

Recombinant Human Glycerol-3-phosphate dehydrogenase 1-like protein (GPD1L) (Active) — recombinant protein from Homo sapiens (Human), expressed in E.coli. Purity >85%.

SKU: BCACP-000049 Categories: ,
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Product SKUBCACP-000049
Product DescriptionRecombinant Human Glycerol-3-phosphate dehydrogenase 1-like protein (GPD1L) protein is expressed from E.coli with N-terminal GST-tagged. It contains 1-351aa. [Accession | Q8N335].
Uniprot No.Q8N335
Gene NamesGPD1L
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region1-351aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal GST-tagged
Molecular weight65.4 kDa
ActivityThe ED50 as determined by the dose-dependent stimulation of the proliferation of THP-1 cells is 0.5913-1.205 ng/mL.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesGPD1L; KIAA0089; Glycerol-3-phosphate dehydrogenase 1-like protein; GPD1-L; EC 1.1.1.8

Function

Plays a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD(H) balance induced by DPD1L.

Biological Context

Subcellular Location: Cytoplasm
Tissue Specificity: Most highly expressed in heart tissue, with lower levels in the skeletal muscle, kidney, lung and other organs
Disease Association: Brugada syndrome 2 (BRGDA2) : A tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs, the individual will faint and may die in a few minutes if the heart is not reset. [The gene represented in this entry may be involved in disease pathogenesis]

Product Specifications

Recombinant Human Glycerol-3-phosphate dehydrogenase 1-like protein (GPD1L) (Active) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 1-351aa, with N-terminal GST-tagged tag, molecular weight 65.4 kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Plays a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD(H) balance induced by DPD1L

Subcellular Location

Cytoplasm

Disease Association

Brugada syndrome 2 (BRGDA2) : A tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs, the individual will faint and may die in a few minutes if the heart is not reset. [The gene represented in this entry may be involved in disease pathogenesis]

Tissue Specificity

Most highly expressed in heart tissue, with lower levels in the skeletal muscle, kidney, lung and other organs

Subunit

Interacts with SCN5A

Gene: GPD1L  |  Organism: Homo sapiens
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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