Recombinant Human Glycerol-3-phosphate dehydrogenase 1-like protein (GPD1L) (Active), Homo sapiens (Human), E.coli, N-terminal GST-tagged, 65.4 kDa, purity >85% as determined by SDS-PAGE.
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Recombinant Human Glycerol-3-phosphate dehydrogenase 1-like protein (GPD1L) (Active)

Recombinant Human Glycerol-3-phosphate dehydrogenase 1-like protein (GPD1L) (Active) — recombinant protein from Homo sapiens (Human), expressed in E.coli. Purity >85%.

SKU: BCACP-000049 Categories: ,
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Product SKUBCACP-000049
Product DescriptionRecombinant Human Glycerol-3-phosphate dehydrogenase 1-like protein (GPD1L) protein is expressed from E.coli with N-terminal GST-tagged. It contains 1-351aa. [Accession | Q8N335].
Uniprot No.Q8N335
Gene NamesGPD1L
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region1-351aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal GST-tagged
Molecular weight65.4 kDa
ActivityThe ED50 as determined by the dose-dependent stimulation of the proliferation of THP-1 cells is 0.5913-1.205 ng/mL.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesGPD1L; KIAA0089; Glycerol-3-phosphate dehydrogenase 1-like protein; GPD1-L; EC 1.1.1.8

Function

Plays a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD(H) balance induced by DPD1L.

Biological Context

Subcellular Location: Cytoplasm
Tissue Specificity: Most highly expressed in heart tissue, with lower levels in the skeletal muscle, kidney, lung and other organs
Disease Association: Brugada syndrome 2 (BRGDA2) : A tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs, the individual will faint and may die in a few minutes if the heart is not reset. [The gene represented in this entry may be involved in disease pathogenesis]

Product Specifications

Recombinant Human Glycerol-3-phosphate dehydrogenase 1-like protein (GPD1L) (Active) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 1-351aa, with N-terminal GST-tagged tag, molecular weight 65.4 kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: The ED50 as determined by the dose-dependent stimulation of the proliferation of THP-1 cells is 0.5913-1.205 ng/mL.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Plays a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD(H) balance induced by DPD1L

Subcellular Location

Cytoplasm

Disease Association

Brugada syndrome 2 (BRGDA2) : A tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs, the individual will faint and may die in a few minutes if the heart is not reset. [The gene represented in this entry may be involved in disease pathogenesis]

Tissue Specificity

Most highly expressed in heart tissue, with lower levels in the skeletal muscle, kidney, lung and other organs

Subunit

Interacts with SCN5A

Gene: GPD1L  |  Organism: Homo sapiens
Key Publications

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Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

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Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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