Recombinant Human Glycogen phosphorylase, liver form (PYGL), partial, Homo sapiens (Human), E.coli, N-terminal GST-tagged, 123.9kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Glycogen phosphorylase, liver form (PYGL), partial

Recombinant Human Glycogen phosphorylase, liver form (PYGL), partial — recombinant protein from Homo sapiens (Human), expressed in E.coli. Purity >90%.

SKU: BCRECP-001494 Category:
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Product Specifications

Product SkuBCRECP-001494
Product DescriptionRecombinant Human Glycogen phosphorylase, liver form (PYGL) Protein is expressed from E.coli with N-terminal GST-tagged. It contains 2-846aa. [Accession | P06737].
Uniprot No.P06737
Gene NamesPYGL
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region2-846aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal GST-tagged
Molecular weight123.9kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasMetabolism

Function

Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.

Biological Context

Subcellular Location: Cytoplasm, cytosol
Disease Association: Glycogen storage disease 6 (GSD6) : A metabolic disorder characterized by mild to moderate hypoglycemia, mild ketosis, growth retardation, and prominent hepatomegaly. Heart and skeletal muscle are not affected. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Glycogen phosphorylase, liver form (PYGL), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 2-846aa, with N-terminal GST-tagged tag, molecular weight 123.9kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis

Subcellular Location

Cytoplasm, cytosol

Disease Association

Glycogen storage disease 6 (GSD6) : A metabolic disorder characterized by mild to moderate hypoglycemia, mild ketosis, growth retardation, and prominent hepatomegaly. Heart and skeletal muscle are not affected. [The disease is caused by variants affecting the gene represented in this entry]

Subunit

Homodimer; enzymatically active (PubMed:10949035, PubMed:10980448). Interacts with PPP1R3B; recruits the phosphatase PP1 which dephosphorylates and inactivates PYGL/glycogen phosphorylase (PubMed:22225877)

Gene: PYGL  |  Organism: Homo sapiens
Key Publications

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How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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