Recombinant Human Growth/differentiation factor 9 (GDF9), Homo sapiens (Human), E.coli, Tag-Free, 15.6kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Growth/differentiation factor 9 (GDF9)

Recombinant Human Growth/differentiation factor 9 (GDF9) — Required for ovarian folliculogenesis. Purity >90%.

SKU: BCRECP-000734 Category:
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Product Specifications

Product SkuBCRECP-000734
Product DescriptionRecombinant Human Growth/differentiation factor 9 (GDF9) Protein is expressed from E.coli with Tag-Free. It contains 320-454aa. [Accession | O60383].
Uniprot No.O60383
Gene NamesGDF9
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region320-454aa
SpeciesHomo sapiens (Human)
Tag InfoTag-Free
Molecular weight15.6kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasCardiovascular

Function

Required for ovarian folliculogenesis. Promotes primordial follicle development. Stimulates granulosa cell proliferation.

Biological Context

Subcellular Location: Secreted
Tissue Specificity: Expressed in ovarian granulosa cells. Present in oocytes of primary follicles (at protein level)
Disease Association: [Altered GDF9 function may be involved in ovarian disorders and contribute to the likelihood of dizygotic twinning] | Premature ovarian failure 14 (POF14) : An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Growth/differentiation factor 9 (GDF9) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 320-454aa, with Tag-Free tag, molecular weight 15.6kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Required for ovarian folliculogenesis. Promotes primordial follicle development. Stimulates granulosa cell proliferation. Promotes cell transition from G0/G1 to S and G2/M phases, through an increase of CCND1 and CCNE1 expression, and RB1 phosphorylation. It regulates STAR expression and cAMP-dependent progesterone release in granulosa and thecal cells. Attenuates the suppressive effects of activin A on STAR expression and progesterone production by increasing the expression of inhibin B. It suppresses FST and FSTL3 production in granulosa-lutein cells

Subcellular Location

Secreted

Disease Association

[Altered GDF9 function may be involved in ovarian disorders and contribute to the likelihood of dizygotic twinning] | Premature ovarian failure 14 (POF14) : An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Expressed in ovarian granulosa cells. Present in oocytes of primary follicles (at protein level)

Subunit

Homodimer or heterodimer (Potential). But, in contrast to other members of this family, cannot be disulfide-linked (By similarity)

Gene: GDF9  |  Organism: Homo sapiens
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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