Recombinant Human Heme oxygenase 1 (HMOX1), partial, Homo sapiens (Human), E.coli, N-terminal 6xHis-tagged, 36.6kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Heme oxygenase 1 (HMOX1), partial

Recombinant Human Heme oxygenase 1 (HMOX1), partial — recombinant protein from Homo sapiens (Human), expressed in E.coli. Purity >90%.

SKU: BCRECP-000842 Category:
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Product Specifications

Product SkuBCRECP-000842
Product DescriptionRecombinant Human Heme oxygenase 1 (HMOX1) Protein is expressed from E.coli with N-terminal 6xHis-tagged. It contains 3-288aa. [Accession | P09601].
Uniprot No.P09601
Gene NamesHMOX1
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region3-288aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-tagged
Molecular weight36.6kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasCardiovascular

Function

Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron.

Biological Context

Subcellular Location: Endoplasmic reticulum membrane (Single-pass type IV membrane protein)
Tissue Specificity: Expressed at higher levels in renal cancer tissue than in normal tissue (at protein level)
Disease Association: Heme oxygenase 1 deficiency (HMOX1D) : A disease characterized by impaired stress hematopoiesis, resulting in marked erythrocyte fragmentation and intravascular hemolysis, coagulation abnormalities, endothelial damage, and iron deposition in renal and hepatic tissues. Clinical features include persistent hemolytic anemia, asplenia, nephritis, generalized erythematous rash, growth retardation and hepatomegaly. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Heme oxygenase 1 (HMOX1), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 3-288aa, with N-terminal 6xHis-tagged tag, molecular weight 36.6kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron

Subcellular Location

Endoplasmic reticulum membrane (Single-pass type IV membrane protein)

Disease Association

Heme oxygenase 1 deficiency (HMOX1D) : A disease characterized by impaired stress hematopoiesis, resulting in marked erythrocyte fragmentation and intravascular hemolysis, coagulation abnormalities, endothelial damage, and iron deposition in renal and hepatic tissues. Clinical features include persistent hemolytic anemia, asplenia, nephritis, generalized erythematous rash, growth retardation and hepatomegaly. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Expressed at higher levels in renal cancer tissue than in normal tissue (at protein level)

Subunit

Homodimer and higher order homooligomer (PubMed:19556236). Oligomerization is crucial for its stability and function in the endoplasmic reticulum (PubMed:19556236). Interacts with FLVCR2; this interaction is potentiated in the presence of heme

Gene: HMOX1  |  Organism: Homo sapiens
Key Publications

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How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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