Recombinant Human Heme oxygenase 1 (HMOX1), partial, Homo sapiens (Human), E.coli, N-terminal 6xHis-tagged, 36.6kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Heme oxygenase 1 (HMOX1), partial

Recombinant Human Heme oxygenase 1 (HMOX1), partial — recombinant protein from Homo sapiens (Human), expressed in E.coli. Purity >90%.

SKU: BCRECP-000842 Category:
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Product Specifications

Product SkuBCRECP-000842
Product DescriptionRecombinant Human Heme oxygenase 1 (HMOX1) Protein is expressed from E.coli with N-terminal 6xHis-tagged. It contains 3-288aa. [Accession | P09601].
Uniprot No.P09601
Gene NamesHMOX1
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region3-288aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-tagged
Molecular weight36.6kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasCardiovascular

Function

Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron.

Biological Context

Subcellular Location: Endoplasmic reticulum membrane (Single-pass type IV membrane protein)
Tissue Specificity: Expressed at higher levels in renal cancer tissue than in normal tissue (at protein level)
Disease Association: Heme oxygenase 1 deficiency (HMOX1D) : A disease characterized by impaired stress hematopoiesis, resulting in marked erythrocyte fragmentation and intravascular hemolysis, coagulation abnormalities, endothelial damage, and iron deposition in renal and hepatic tissues. Clinical features include persistent hemolytic anemia, asplenia, nephritis, generalized erythematous rash, growth retardation and hepatomegaly. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Heme oxygenase 1 (HMOX1), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 3-288aa, with N-terminal 6xHis-tagged tag, molecular weight 36.6kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

Related products

Protein Biology

Function

Catalyzes the oxidative cleavage of heme at the alpha-methene bridge carbon, released as carbon monoxide (CO), to generate biliverdin IXalpha, while releasing the central heme iron chelate as ferrous iron

Subcellular Location

Endoplasmic reticulum membrane (Single-pass type IV membrane protein)

Disease Association

Heme oxygenase 1 deficiency (HMOX1D) : A disease characterized by impaired stress hematopoiesis, resulting in marked erythrocyte fragmentation and intravascular hemolysis, coagulation abnormalities, endothelial damage, and iron deposition in renal and hepatic tissues. Clinical features include persistent hemolytic anemia, asplenia, nephritis, generalized erythematous rash, growth retardation and hepatomegaly. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Expressed at higher levels in renal cancer tissue than in normal tissue (at protein level)

Subunit

Homodimer and higher order homooligomer (PubMed:19556236). Oligomerization is crucial for its stability and function in the endoplasmic reticulum (PubMed:19556236). Interacts with FLVCR2; this interaction is potentiated in the presence of heme

Gene: HMOX1  |  Organism: Homo sapiens
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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