Recombinant Human Hepatic sodium/bile acid cotransporter (SLC10A1) Protein, Homo sapiens (Human), in vitro E.coli expression system, C-terminal 10xHis-tagged, 39.5kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Hepatic sodium/bile acid cotransporter (SLC10A1) Protein

Recombinant Human Hepatic sodium/bile acid cotransporter (SLC10A1) Protein — (Microbial infection) Acts as an entry receptor for hepatitis B virus (HBV). Purity >90%.

SKU: BCRECP-00449TM Category:
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Product Specifications

Uniprot No.Q14973
Gene NamesSLC10A1
PurityGreater than 90% as determined by SDS-PAGE.
Expression Systemin vitro E.coli expression system
Expression Region1-349aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal 10xHis-tagged
Molecular weight39.5kDa
ActivityNot Test
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Function

(Microbial infection) Acts as an entry receptor for hepatitis B virus (HBV). The recognition for human SLC10A1/NTCP is highly specific.

Biological Context

Subcellular Location: Cell membrane (Multi-pass membrane protein)
Tissue Specificity: Expressed in liver. Expressed in placental trophoblasts
Disease Association: Hypercholanemia, familial, 2 (FHCA2) : An autosomal recessive inborn error of metabolism characterized by persistently increased plasma levels of conjugated bile salts apparent from infancy, fat malabsorption and impaired absorption of fat-soluble vitamins, including D and K. Most patients are asymptomatic. Some neonates may have transient jaundice or transiently elevated liver enzymes. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Hepatic sodium/bile acid cotransporter (SLC10A1) Protein is a recombinant protein from Homo sapiens (Human), expressed in in vitro E.coli expression system, covering amino acids 1-349aa, with C-terminal 10xHis-tagged tag, molecular weight 39.5kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

(Microbial infection) Acts as an entry receptor for hepatitis B virus (HBV) (PubMed:23150796). The recognition for human SLC10A1/NTCP is highly specific (PubMed:35545671, PubMed:35580629, PubMed:35580630, PubMed:38233573)

Subcellular Location

Cell membrane (Multi-pass membrane protein)

Disease Association

Hypercholanemia, familial, 2 (FHCA2) : An autosomal recessive inborn error of metabolism characterized by persistently increased plasma levels of conjugated bile salts apparent from infancy, fat malabsorption and impaired absorption of fat-soluble vitamins, including D and K. Most patients are asymptomatic. Some neonates may have transient jaundice or transiently elevated liver enzymes. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Expressed in liver (PubMed:11031103, PubMed:12409283). Expressed in placental trophoblasts (PubMed:12409283)

Subunit

(Microbial infection) Interacts with the myristoylated pre-S1 domain of hepatitis B virus large envelope protein; myristoylation is essential for this interaction

Gene: SLC10A1  |  Organism: Homo sapiens  |  Synonyms: Cell growth-inhibiting gene 29 protein; Na(+)/bile acid cotransporter; Na(+)/taurocholate transport protein; Sodium/taurocholate cotransporting polypeptide; Solute carrier family 10 member 1
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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