Recombinant Human herpesvirus 1 Envelope glycoprotein D (gD), partial, Human herpesvirus 1 (strain KOS) (HHV-1) (Human herpes simplex virus 1), E.coli, N-terminal 10xHis-tagged and C-terminal Myc-tagged, 42.3kDa, purity >85% as determined by SDS-PAGE.
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Recombinant Human herpesvirus 1 Envelope glycoprotein D (gD), partial

Recombinant Human herpesvirus 1 Envelope glycoprotein D (gD), partial — Envelope glycoprotein that binds to the host cell entry receptors NECTIN1, TNFRSF14/HVEM and 3-O-sulfated heparan sulfate, promoting the virus entry into host cells. Purity >85%.

SKU: BCRECP-002836 Categories: ,
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Product Specifications

Product SkuBCRECP-002836
Product DescriptionRecombinant Human herpesvirus 1 Envelope glycoprotein D (gD) Protein is expressed from E.coli with N-terminal 10xHis-tagged and C-terminal Myc-tagged. It contains 26-340aa. [Accession | A1Z0Q5].
Uniprot No.A1Z0Q5
Gene NamesgD
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region26-340aa
SpeciesHuman herpesvirus 1 (strain KOS) (HHV-1) (Human herpes simplex virus 1)
Tag InfoN-terminal 10xHis-tagged and C-terminal Myc-tagged
Molecular weight42.3kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasMicrobiology

Function

Envelope glycoprotein that binds to the host cell entry receptors NECTIN1, TNFRSF14/HVEM and 3-O-sulfated heparan sulfate, promoting the virus entry into host cells. May trigger fusion with host membrane, by recruiting the fusion machinery composed of gB and gH/gL.

Biological Context

Subcellular Location: Virion membrane (Single-pass type I membrane protein); Host Golgi apparatus

Product Specifications

Recombinant Human herpesvirus 1 Envelope glycoprotein D (gD), partial is a recombinant protein from Human herpesvirus 1 (strain KOS) (HHV-1) (Human herpes simplex virus 1), expressed in E.coli, covering amino acids 26-340aa, with N-terminal 10xHis-tagged and C-terminal Myc-tagged tag, molecular weight 42.3kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Envelope glycoprotein that binds to the host cell entry receptors NECTIN1, TNFRSF14/HVEM and 3-O-sulfated heparan sulfate, promoting the virus entry into host cells (PubMed:39048823, PubMed:39048830, PubMed:9696799). May trigger fusion with host membrane, by recruiting the fusion machinery composed of gB and gH/gL (By similarity)

Subcellular Location

Virion membrane (Single-pass type I membrane protein); Host Golgi apparatus

Subunit

Homodimer (By similarity). Interacts with host receptor TNFRSF14. Interacts with host receptor NECTIN1. Mutant Rid1 interacts with host receptor NECTIN2. Interacts (via profusion domain) with gB; this interaction occurs in the absence of gH/gL. Interacts (via profusion domain) with gH/gL heterodimer; this interaction occurs in the absence of gB. Associates with the gB-gH/gL-gD complex. Interacts (via C-terminus) with UL11 tegument protein. Interacts (via C-terminus) with VP22 tegument protein; this interaction might be very weak (By similarity). Interacts with host RSAD2 (By similarity)

Gene: gD  |  Organism: Human herpesvirus 1 (strain KOS)
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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