Recombinant Human herpesvirus 1 Envelope glycoprotein D (gD), partial, Human herpesvirus 1 (strain KOS) (HHV-1) (Human herpes simplex virus 1), E.coli, N-terminal 10xHis-tagged and C-terminal Myc-tagged, 42.3kDa, purity >85% as determined by SDS-PAGE.
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Recombinant Human herpesvirus 1 Envelope glycoprotein D (gD), partial

Recombinant Human herpesvirus 1 Envelope glycoprotein D (gD), partial — Envelope glycoprotein that binds to the host cell entry receptors NECTIN1, TNFRSF14/HVEM and 3-O-sulfated heparan sulfate, promoting the virus entry into host cells. Purity >85%.

SKU: BCRECP-002836 Categories: ,
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Product Specifications

Product SkuBCRECP-002836
Product DescriptionRecombinant Human herpesvirus 1 Envelope glycoprotein D (gD) Protein is expressed from E.coli with N-terminal 10xHis-tagged and C-terminal Myc-tagged. It contains 26-340aa. [Accession | A1Z0Q5].
Uniprot No.A1Z0Q5
Gene NamesgD
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region26-340aa
SpeciesHuman herpesvirus 1 (strain KOS) (HHV-1) (Human herpes simplex virus 1)
Tag InfoN-terminal 10xHis-tagged and C-terminal Myc-tagged
Molecular weight42.3kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasMicrobiology

Function

Envelope glycoprotein that binds to the host cell entry receptors NECTIN1, TNFRSF14/HVEM and 3-O-sulfated heparan sulfate, promoting the virus entry into host cells. May trigger fusion with host membrane, by recruiting the fusion machinery composed of gB and gH/gL.

Biological Context

Subcellular Location: Virion membrane (Single-pass type I membrane protein); Host Golgi apparatus

Product Specifications

Recombinant Human herpesvirus 1 Envelope glycoprotein D (gD), partial is a recombinant protein from Human herpesvirus 1 (strain KOS) (HHV-1) (Human herpes simplex virus 1), expressed in E.coli, covering amino acids 26-340aa, with N-terminal 10xHis-tagged and C-terminal Myc-tagged tag, molecular weight 42.3kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Envelope glycoprotein that binds to the host cell entry receptors NECTIN1, TNFRSF14/HVEM and 3-O-sulfated heparan sulfate, promoting the virus entry into host cells (PubMed:39048823, PubMed:39048830, PubMed:9696799). May trigger fusion with host membrane, by recruiting the fusion machinery composed of gB and gH/gL (By similarity)

Subcellular Location

Virion membrane (Single-pass type I membrane protein); Host Golgi apparatus

Subunit

Homodimer (By similarity). Interacts with host receptor TNFRSF14. Interacts with host receptor NECTIN1. Mutant Rid1 interacts with host receptor NECTIN2. Interacts (via profusion domain) with gB; this interaction occurs in the absence of gH/gL. Interacts (via profusion domain) with gH/gL heterodimer; this interaction occurs in the absence of gB. Associates with the gB-gH/gL-gD complex. Interacts (via C-terminus) with UL11 tegument protein. Interacts (via C-terminus) with VP22 tegument protein; this interaction might be very weak (By similarity). Interacts with host RSAD2 (By similarity)

Gene: gD  |  Organism: Human herpesvirus 1 (strain KOS)
Key Publications

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How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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