Recombinant Human herpesvirus 2 Tegument protein VP22 (UL49) Protein, Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2), in vitro E.coli expression system, N-terminal 6xHis-B2M-tagged, 45.8kDa, purity >90% as determined by SDS-PAGE.
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Recombinant Human herpesvirus 2 Tegument protein VP22 (UL49) Protein

Recombinant Human herpesvirus 2 Tegument protein VP22 (UL49) Protein — Tegument protein that plays different roles during the time course of infection. Purity >90%.

SKU: BCRECP-00659TM Categories: ,
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Product Specifications

Uniprot No.P89468
Gene NamesUL49
PurityGreater than 90% as determined by SDS-PAGE.
Expression Systemin vitro E.coli expression system
Expression Region1-300aa
SpeciesHuman herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2)
Tag InfoN-terminal 6xHis-B2M-tagged
Molecular weight45.8kDa
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Function

Tegument protein that plays different roles during the time course of infection. Participates in both the accumulation of viral mRNAs and viral protein translation at late time of infection. Modulates the RNase activity of the virion host shutoff protein UL41 probably to ensure necessary levels of key cellular mRNAs and proteins.

Biological Context

Subcellular Location: Virion tegument; Host cytoplasm; Host nucleus; Host Golgi apparatus

Product Specifications

Recombinant Human herpesvirus 2 Tegument protein VP22 (UL49) Protein is a recombinant protein from Human herpesvirus 2 (strain HG52) (HHV-2) (Human herpes simplex virus 2), expressed in in vitro E.coli expression system, covering amino acids 1-300aa, with N-terminal 6xHis-B2M-tagged tag, molecular weight 45.8kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Tegument protein that plays different roles during the time course of infection (By similarity). Participates in both the accumulation of viral mRNAs and viral protein translation at late time of infection (By similarity). Modulates the RNase activity of the virion host shutoff protein UL41 probably to ensure necessary levels of key cellular mRNAs and proteins (By similarity). Plays a role in microtubule reorganization that occurs after viral infection by stabilizing microtubule network (By similarity). Plays a role in the inhibition of host innate immune system by targeting the CGAS enzymatic activity which is the principal cytosolic DNA sensor that detects invading viral DNA. Acts by mediating disruption of liquid-like droplets in which CGAS is activated, thereby preventing CGAS activity (By similarity)

Subcellular Location

Virion tegument; Host cytoplasm; Host nucleus; Host Golgi apparatus

Subunit

Interacts with gE (via C-terminus); this interaction is necessary for the recruitment of VP22 to the Golgi and its packaging into virions (By similarity). Interacts with gM (via C-terminus) (By similarity). Interacts with VP16; this interaction allows the formation of a tripartite complex composed of VP16, VP22 and UL41/VHS (By similarity). Interacts with the capsid-binding protein UL16 (By similarity). Interacts with host CGAS (By similarity)

Organism: Human herpesvirus 2 (strain HG52)

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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