Recombinant Human High affinity immunoglobulin epsilon receptor subunit alpha (FCER1A), partial, Homo sapiens (Human), E.coli, N-terminal 6xHis-SUMO-tagged, 37.0kDa, purity >90% as determined by SDS-PAGE.
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Recombinant Human High affinity immunoglobulin epsilon receptor subunit alpha (FCER1A), partial

Recombinant Human High affinity immunoglobulin epsilon receptor subunit alpha (FCER1A), partial — High-affinity receptor for immunoglobulin epsilon/IgE. Purity >90%.

SKU: BCRECP-000641 Categories: ,
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Product Specifications

Product SkuBCRECP-000641
Product DescriptionRecombinant Human High affinity immunoglobulin epsilon receptor subunit alpha (FCER1A) Protein is expressed from E.coli with N-terminal 6xHis-SUMO-tagged. It contains 26-205aa. [Accession | P12319].
Uniprot No.P12319
Gene NamesFCER1A
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region26-205aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-SUMO-tagged
Molecular weight37.0kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasImmunology

Function

High-affinity receptor for immunoglobulin epsilon/IgE. Mediates IgE effector functions in myeloid cells. Upon IgE binding and antigen/allergen cross-linking initiates signaling pathways that lead to myeloid cell activation and differentiation.

Biological Context

Subcellular Location: Cell membrane (Single-pass type I membrane protein)
Tissue Specificity: Expressed in eosinophils

Product Specifications

Recombinant Human High affinity immunoglobulin epsilon receptor subunit alpha (FCER1A), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 26-205aa, with N-terminal 6xHis-SUMO-tagged tag, molecular weight 37.0kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

High-affinity receptor for immunoglobulin epsilon/IgE. Mediates IgE effector functions in myeloid cells. Upon IgE binding and antigen/allergen cross-linking initiates signaling pathways that lead to myeloid cell activation and differentiation. On mast cells, basophils and eosinophils stimulates the secretion of vasoactive amines, lipid mediators and cytokines that contribute to inflammatory response, tissue remodeling and cytotoxicity against microbes. Triggers the immediate hypersensitivity response to allergens as a host defense mechanism against helminth parasites, pathogenic bacteria and venom toxicity. When dysregulated, it can elicit harmful life-threatening allergic and anaphylactic reactions

Subcellular Location

Cell membrane (Single-pass type I membrane protein)

Tissue Specificity

Expressed in eosinophils

Subunit

Tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains. Interacts with IGHE (via CH3 region)

Gene: FCER1A  |  Organism: Homo sapiens  |  Synonyms: Fc-epsilon RI-alpha; IgE Fc receptor subunit alpha
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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