Recombinant Human Hyaluronidase-1 (HYAL1), partial, Homo sapiens (Human), Mammalian cell, C-terminal hFc1-tagged, 46.7kDa, purity >85% as determined by SDS-PAGE.

Recombinant Human Hyaluronidase-1 (HYAL1), partial

Recombinant Human Hyaluronidase-1 (HYAL1), partial — May have a role in promoting tumor progression. Purity >85%.

SKU: BCRECP-000873 Category:
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Product Specifications

Product SkuBCRECP-000873
Product DescriptionRecombinant Human Hyaluronidase-1 (HYAL1) Protein is expressed from Mammalian cell with C-terminal hFc1-tagged. It contains 273-435aa. [Accession | Q12794].
Uniprot No.Q12794
Gene NamesHYAL1
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region273-435aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal hFc1-tagged
Molecular weight46.7kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasCancer

Function

May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth.

Biological Context

Subcellular Location: Secreted; Lysosome
Tissue Specificity: Highly expressed in the liver, kidney and heart. Weakly expressed in lung, placenta and skeletal muscle. No expression detected in adult brain. Isoform 1 is expressed only in bladder and prostate cancer cells, G2/G3 bladder tumor tissues and lymph node specimens showing tumor invasive tumors cells. Isoform 3, isoform 4, isoform 5 and isoform 6 are expressed in normal bladder and bladder tumor tissues
Disease Association: Mucopolysaccharidosis 9 (MPS9) : A form of mucopolysaccharidosis, a group of lysosomal storage diseases characterized by defective degradation of glycosaminoglycans, resulting in their excessive accumulation and secretion. The diseases are progressive and often display a wide spectrum of clinical severity. MPS9 is an autosomal recessive form characterized by high hyaluronan concentration in the serum. Clinical features include periarticular soft tissue masses, mild short stature and acetabular erosions, and absence of neurological or visceral involvement. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Hyaluronidase-1 (HYAL1), partial is a recombinant protein from Homo sapiens (Human), expressed in Mammalian cell, covering amino acids 273-435aa, with C-terminal hFc1-tagged tag, molecular weight 46.7kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

May have a role in promoting tumor progression. May block the TGFB1-enhanced cell growth

Subcellular Location

Secreted; Lysosome

Disease Association

Mucopolysaccharidosis 9 (MPS9) : A form of mucopolysaccharidosis, a group of lysosomal storage diseases characterized by defective degradation of glycosaminoglycans, resulting in their excessive accumulation and secretion. The diseases are progressive and often display a wide spectrum of clinical severity. MPS9 is an autosomal recessive form characterized by high hyaluronan concentration in the serum. Clinical features include periarticular soft tissue masses, mild short stature and acetabular erosions, and absence of neurological or visceral involvement. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Highly expressed in the liver, kidney and heart. Weakly expressed in lung, placenta and skeletal muscle. No expression detected in adult brain. Isoform 1 is expressed only in bladder and prostate cancer cells, G2/G3 bladder tumor tissues and lymph node specimens showing tumor invasive tumors cells. Isoform 3, isoform 4, isoform 5 and isoform 6 are expressed in normal bladder and bladder tumor tissues

Gene: HYAL1  |  Organism: Homo sapiens  |  Synonyms: Hyaluronoglucosaminidase-1; Lung carcinoma protein 1
Key Publications

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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