Recombinant Human Hyaluronidase-2 (HYAL2), Homo sapiens (Human), Yeast, N-terminal 6xHis-tagged, 51.3kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Hyaluronidase-2 (HYAL2)

Recombinant Human Hyaluronidase-2 (HYAL2) — Catalyzes hyaluronan degradation into small fragments that are endocytosed and degraded in lysosomes by HYAL1 and exoglycosidases. Purity >90%.

SKU: BCRECP-000874 Category:
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Product Specifications

Product SkuBCRECP-000874
Product DescriptionRecombinant Human Hyaluronidase-2 (HYAL2) Protein is expressed from Yeast with N-terminal 6xHis-tagged. It contains 21-448aa. [Accession | Q12891].
Uniprot No.Q12891
Gene NamesHYAL2
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemYeast
Expression Region21-448aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-tagged
Molecular weight51.3kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasCancer

Function

Catalyzes hyaluronan degradation into small fragments that are endocytosed and degraded in lysosomes by HYAL1 and exoglycosidases. Essential for the breakdown of extracellular matrix hyaluronan.

Biological Context

Subcellular Location: Cell membrane (Lipid-anchor, GPI-anchor)
Tissue Specificity: Widely expressed (at protein level)
Disease Association: Muggenthaler-Chowdhury-Chioza syndrome (MCCS) : An autosomal recessive disorder characterized by distinctive craniofacial dysmorphism with frontal bossing, hypertelorism, a broad and flattened nasal tip, and cupped ears with superior helices. Other common but variable clinical manifestations are unilateral or bilateral cleft lip and palate, congenital cardiac anomalies, ocular features including mild to severe myopia and cataracts, single palmar crease, and pectus excavatum. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Hyaluronidase-2 (HYAL2) is a recombinant protein from Homo sapiens (Human), expressed in Yeast, covering amino acids 21-448aa, with N-terminal 6xHis-tagged tag, molecular weight 51.3kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

Related products

Protein Biology

Function

Catalyzes hyaluronan degradation into small fragments that are endocytosed and degraded in lysosomes by HYAL1 and exoglycosidases (PubMed:9712871). Essential for the breakdown of extracellular matrix hyaluronan (PubMed:28081210)

Subcellular Location

Cell membrane (Lipid-anchor, GPI-anchor)

Disease Association

Muggenthaler-Chowdhury-Chioza syndrome (MCCS) : An autosomal recessive disorder characterized by distinctive craniofacial dysmorphism with frontal bossing, hypertelorism, a broad and flattened nasal tip, and cupped ears with superior helices. Other common but variable clinical manifestations are unilateral or bilateral cleft lip and palate, congenital cardiac anomalies, ocular features including mild to severe myopia and cataracts, single palmar crease, and pectus excavatum. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Widely expressed (at protein level)

Subunit

Interacts with MST1R

Gene: HYAL2  |  Organism: Homo sapiens  |  Synonyms: Hyaluronoglucosaminidase-2; Lung carcinoma protein 2
Key Publications

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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