Recombinant Human Hypoxanthine-guanine phosphoribosyltransferase (HPRT1), Homo sapiens (Human), E.coli, N-terminal 6xHis-tagged, 28.4kDa, purity >90% as determined by SDS-PAGE.
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Recombinant Human Hypoxanthine-guanine phosphoribosyltransferase (HPRT1)

Recombinant Human Hypoxanthine-guanine phosphoribosyltransferase (HPRT1) — Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Purity >90%.

SKU: BCRECP-000856 Categories: ,
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Product Specifications

Product SkuBCRECP-000856
Product DescriptionRecombinant Human Hypoxanthine-guanine phosphoribosyltransferase (HPRT1) Protein is expressed from E.coli with N-terminal 6xHis-tagged. It contains 2-218aa. [Accession | P00492].
Uniprot No.P00492
Gene NamesHPRT1
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region2-218aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-tagged
Molecular weight28.4kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasMetabolism

Function

Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway.

Biological Context

Subcellular Location: Cytoplasm
Disease Association: Lesch-Nyhan syndrome (LNS) : Characterized by complete lack of enzymatic activity that results in hyperuricemia, choreoathetosis, intellectual disability, and compulsive self-mutilation. [The disease is caused by variants affecting the gene represented in this entry] | Hyperuricemia, HPRT-related (HRH) : An X-linked metabolic disorder characterized by uric acid excess in the blood, renal stones, uric acid nephropathy, and renal obstruction. After puberty, the hyperuricemia may cause gout. [The disease is caused by variants affecting the gene represented in this entry]
Pathway: Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1

Product Specifications

Recombinant Human Hypoxanthine-guanine phosphoribosyltransferase (HPRT1) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 2-218aa, with N-terminal 6xHis-tagged tag, molecular weight 28.4kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway

Subcellular Location

Cytoplasm

Disease Association

Lesch-Nyhan syndrome (LNS) : Characterized by complete lack of enzymatic activity that results in hyperuricemia, choreoathetosis, intellectual disability, and compulsive self-mutilation. [The disease is caused by variants affecting the gene represented in this entry] | Hyperuricemia, HPRT-related (HRH) : An X-linked metabolic disorder characterized by uric acid excess in the blood, renal stones, uric acid nephropathy, and renal obstruction. After puberty, the hyperuricemia may cause gout. [The disease is caused by variants affecting the gene represented in this entry]

Subunit

Homotetramer

Pathway

Purine metabolism; IMP biosynthesis via salvage pathway; IMP from hypoxanthine: step 1/1

Gene: HPRT1  |  Organism: Homo sapiens

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Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

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Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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