Recombinant Human Inosine-5’-monophosphate dehydrogenase 2 (IMPDH2), partial, Homo sapiens (Human), E.coli, C-terminal 6xHis-tagged, 62.2kDa, purity >90% as determined by SDS-PAGE.
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Recombinant Human Inosine-5’-monophosphate dehydrogenase 2 (IMPDH2), partial

Recombinant Human Inosine-5’-monophosphate dehydrogenase 2 (IMPDH2), partial — Catalyzes the conversion of inosine 5′-phosphate (IMP) to xanthosine 5′-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore pl… Purity >90%.

SKU: BCRECP-000970 Categories: ,
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Product Specifications

Product SkuBCRECP-000970
Product DescriptionRecombinant Human Inosine-5’-monophosphate dehydrogenase 2 (IMPDH2) Protein is expressed from E.coli with C-terminal 6xHis-tagged. It contains 5-514aa. [Accession | P12268].
Uniprot No.P12268
Gene NamesIMPDH2
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region5-514aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal 6xHis-tagged
Molecular weight62.2kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasCancer

Function

Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.

Biological Context

Pathway: Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1

Product Specifications

Recombinant Human Inosine-5’-monophosphate dehydrogenase 2 (IMPDH2), partial is a recombinant protein, expressed in E.coli, covering amino acids 5-514aa, with C-terminal 6xHis-tagged tag, molecular weight 62.2kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (PubMed:7763314, PubMed:7903306). Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism (PubMed:14766016). It may also have a role in the development of malignancy and the growth progression of some tumors

Pathway

Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1

Gene: IMPDH2  |  Organism: Homo sapiens

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Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

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Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

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Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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