Recombinant Human Insulin-like growth factor 1 receptor (IGF1R), partial (Active), Homo sapiens (Human), Mammalian cell, C-terminal 10xHis-tagged, 104.2 kDa, purity >90% as determined by SEC-HPLC.Greater than 95% as determined by SDS-PAGE.
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Recombinant Human Insulin-like growth factor 1 receptor (IGF1R), partial (Active)

Recombinant Human Insulin-like growth factor 1 receptor (IGF1R), partial (Active) — When present in a hybrid receptor with INSR, binds IGF1. Purity >90%.

SKU: BCACP-000468 Categories: ,
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Product SKUBCACP-000468
Product DescriptionRecombinant Human Insulin-like growth factor 1 receptor (IGF1R) protein is expressed from Mammalian cell with C-terminal 10xHis-tagged. It contains 31-932aa. [Accession | P08069].
Uniprot No.P08069
Gene NamesIGF1R
PurityGreater than 90% as determined by SEC-HPLC.Greater than 95% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region31-932aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal 10xHis-tagged
Molecular weight104.2 kDa
ActivityMeasured by its binding ability in a functional ELISA. Immobilized Human EPHA2 at 2 μg/mL can bind Anti-EPHA2 recombinant antibody . The EC50 is 36.24-50.53 ng/mL.;Measured by its binding ability in a functional ELISA. Immobilized Human EPHA2 at 2 μg/mL can bind Human EFNA1 . The EC50 is 5.859-7.758 ng/mL.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesInsulin-like growth factor 1 receptor; EC:2.7.10.1; Insulin-like growth factor I receptor (IGF-I receptor); CD221; IGF1R

Function

When present in a hybrid receptor with INSR, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin.

Product Specifications

Recombinant Human Insulin-like growth factor 1 receptor (IGF1R), partial (Active) is a recombinant protein, expressed in Mammalian cell, covering amino acids 31-932aa, with C-terminal 10xHis-tagged tag, molecular weight 104.2 kDa, purity Greater than 90% as determined by SEC-HPLC.Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Measured by its binding ability in a functional ELISA. Immobilized Human EPHA2 at 2 μg/mL can bind Anti-EPHA2 recombinant antibody . The EC50 is 36.24-50.53 ng/mL.;Measured by its binding ability in a functional ELISA. Immobilized Human EPHA2 at 2 μg/mL can bind Human EFNA1 . The EC50 is 5.859-7.758 ng/mL.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

When present in a hybrid receptor with INSR, binds IGF1. PubMed:12138094 shows that hybrid receptors composed of IGF1R and INSR isoform Long are activated with a high affinity by IGF1, with low affinity by IGF2 and not significantly activated by insulin, and that hybrid receptors composed of IGF1R and INSR isoform Short are activated by IGF1, IGF2 and insulin. In contrast, PubMed:16831875 shows that hybrid receptors composed of IGF1R and INSR isoform Long and hybrid receptors composed of IGF1R and INSR isoform Short have similar binding characteristics, both bind IGF1 and have a low affinity for insulin

Gene: IGF1R  |  Organism: Homo sapiens

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Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

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Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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