Recombinant Human Insulin-like growth factor-binding protein 7 (IGFBP7) (Active), Homo sapiens (Human), Mammalian cell, C-terminal hFc1-tagged, 55.4 kDa, purity >95% as determined by SDS-PAGE.
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Recombinant Human Insulin-like growth factor-binding protein 7 (IGFBP7) (Active)

Recombinant Human Insulin-like growth factor-binding protein 7 (IGFBP7) (Active) — Binds IGF1 and IGF2 with a relatively low affinity. Purity >95%.

SKU: BCACP-000231 Categories: ,
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Product SKUBCACP-000231
Product DescriptionRecombinant Human Insulin-like growth factor-binding protein 7 (IGFBP7) protein is expressed from Mammalian cell with C-terminal hFc1-tagged. It contains 27-282aa. [Accession | Q16270].
Uniprot No.Q16270
Gene NamesIGFBP7
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region27-282aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal hFc1-tagged
Molecular weight55.4 kDa
ActivityMeasured by its binding ability in a functional ELISA. Immobilized Macaca fascicularis CDH17 at 2 μg/mL can bind Anti-CDH17 recombinant antibody . The EC50 is 2.182-2.529 ng/mL.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesInsulin-like growth factor-binding protein 7; IBP-7; IGF-binding protein 7; IGFBP-7; IGFBP-rP1; MAC25 protein; PGI2-stimulating factor; Prostacyclin-stimulating factor; Tumor-derived adhesion factor (TAF); IGFBP7;MAC25, PSF

Function

Binds IGF1 and IGF2 with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion.

Biological Context

Subcellular Location: Secreted
Disease Association: Retinal arterial macroaneurysm with supravalvular pulmonic stenosis (RAMSVPS) : An autosomal recessive condition characterized by the bilateral appearance of 'beading' along the major retinal arterial trunks, with the subsequent formation of macroaneurysms. Affected individuals also have supravalvular pulmonic stenosis, often requiring surgical correction. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Insulin-like growth factor-binding protein 7 (IGFBP7) (Active) is a recombinant protein from Homo sapiens (Human), expressed in Mammalian cell, covering amino acids 27-282aa, with C-terminal hFc1-tagged tag, molecular weight 55.4 kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Measured by its binding ability in a functional ELISA. Immobilized Macaca fascicularis CDH17 at 2 μg/mL can bind Anti-CDH17 recombinant antibody . The EC50 is 2.182-2.529 ng/mL.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Binds IGF1 and IGF2 with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion. Acts as a ligand for CD93 to play a role in angiogenesis (PubMed:38218180)

Subcellular Location

Secreted

Disease Association

Retinal arterial macroaneurysm with supravalvular pulmonic stenosis (RAMSVPS) : An autosomal recessive condition characterized by the bilateral appearance of 'beading' along the major retinal arterial trunks, with the subsequent formation of macroaneurysms. Affected individuals also have supravalvular pulmonic stenosis, often requiring surgical correction. [The disease is caused by variants affecting the gene represented in this entry]

Subunit

May interact with VPS24/CHMP3; the relevance of such interaction however remains unclear. Interacts with CD93; this interaction plays a role in endothelial cells angiogenesis (PubMed:38218180)

Gene: IGFBP7  |  Organism: Homo sapiens  |  Synonyms: IGFBP-rP1; MAC25 protein; PGI2-stimulating factor; Prostacyclin-stimulating factor; Tumor-derived adhesion factor
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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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