Recombinant Human Insulin-like growth factor-binding protein 7 (IGFBP7) (Active), Homo sapiens (Human), Mammalian cell, C-terminal hFc1-tagged, 55.4 kDa, purity >95% as determined by SDS-PAGE.
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Recombinant Human Insulin-like growth factor-binding protein 7 (IGFBP7) (Active)

Recombinant Human Insulin-like growth factor-binding protein 7 (IGFBP7) (Active) — Binds IGF1 and IGF2 with a relatively low affinity. Purity >95%.

SKU: BCACP-000231 Categories: ,
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Product SKUBCACP-000231
Product DescriptionRecombinant Human Insulin-like growth factor-binding protein 7 (IGFBP7) protein is expressed from Mammalian cell with C-terminal hFc1-tagged. It contains 27-282aa. [Accession | Q16270].
Uniprot No.Q16270
Gene NamesIGFBP7
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region27-282aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal hFc1-tagged
Molecular weight55.4 kDa
ActivityMeasured by its binding ability in a functional ELISA. Immobilized Macaca fascicularis CDH17 at 2 μg/mL can bind Anti-CDH17 recombinant antibody . The EC50 is 2.182-2.529 ng/mL.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesInsulin-like growth factor-binding protein 7; IBP-7; IGF-binding protein 7; IGFBP-7; IGFBP-rP1; MAC25 protein; PGI2-stimulating factor; Prostacyclin-stimulating factor; Tumor-derived adhesion factor (TAF); IGFBP7;MAC25, PSF

Function

Binds IGF1 and IGF2 with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion.

Biological Context

Subcellular Location: Secreted
Disease Association: Retinal arterial macroaneurysm with supravalvular pulmonic stenosis (RAMSVPS) : An autosomal recessive condition characterized by the bilateral appearance of 'beading' along the major retinal arterial trunks, with the subsequent formation of macroaneurysms. Affected individuals also have supravalvular pulmonic stenosis, often requiring surgical correction. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Insulin-like growth factor-binding protein 7 (IGFBP7) (Active) is a recombinant protein from Homo sapiens (Human), expressed in Mammalian cell, covering amino acids 27-282aa, with C-terminal hFc1-tagged tag, molecular weight 55.4 kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Binds IGF1 and IGF2 with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion. Acts as a ligand for CD93 to play a role in angiogenesis (PubMed:38218180)

Subcellular Location

Secreted

Disease Association

Retinal arterial macroaneurysm with supravalvular pulmonic stenosis (RAMSVPS) : An autosomal recessive condition characterized by the bilateral appearance of 'beading' along the major retinal arterial trunks, with the subsequent formation of macroaneurysms. Affected individuals also have supravalvular pulmonic stenosis, often requiring surgical correction. [The disease is caused by variants affecting the gene represented in this entry]

Subunit

May interact with VPS24/CHMP3; the relevance of such interaction however remains unclear. Interacts with CD93; this interaction plays a role in endothelial cells angiogenesis (PubMed:38218180)

Gene: IGFBP7  |  Organism: Homo sapiens  |  Synonyms: IGFBP-rP1; MAC25 protein; PGI2-stimulating factor; Prostacyclin-stimulating factor; Tumor-derived adhesion factor
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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