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Recombinant Human Insulin-like growth factor II (IGF2) (E30R, F43L, S63P) (Active)

Recombinant Human Insulin-like growth factor II (IGF2) (E30R, F43L, S63P) (Active) — Preptin undergoes glucose-mediated co-secretion with insulin, and acts as a physiological amplifier of glucose-mediated insulin secretion. Purity >95%.

SKU: BCACP-000596 Categories: ,
Product SKUBCACP-000596
Product DescriptionRecombinant Human Insulin-like growth factor II (IGF2) (E30R, F43L, S63P) protein is expressed from Mammalian cell with N-terminal 6xHis-tagged. It contains 25-180aa(E30R,F43L,S63P). [Accession | P01344].
Uniprot No.P01344
Gene NamesIGF2
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region25-180aa(E30R,F43L,S63P)
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-tagged
Molecular weight20.1 kDa
ActivityMeasured by its binding ability in a functional ELISA.Immobilized Human IL3RA at 2 μg/mL can bind Anti-IL3RA recombinant antibody.The EC50 is 1.254-1.412 ng/mL.;IL3RA Recombinant Monoclonal Antibody captured on Protein A Chip can bind Human IL3RA with an affinity constant of 0.202 nM as detected by MetaSPR Assay (WeSPRTM 200).
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesInsulin-like growth factor 2; Insulin-like growth factor II; IGF-II; Somatomedin-A; T3M-11-derived growth factor [Cleaved into: Insulin-like growth factor II Ala-25 Del; Preptin]

Function

Preptin undergoes glucose-mediated co-secretion with insulin, and acts as a physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.

Product Specifications

Recombinant Human Insulin-like growth factor II (IGF2) (E30R, F43L, S63P) (Active) is a recombinant protein, expressed in Mammalian cell, covering amino acids 25-180aa(E30R,F43L,S63P), with N-terminal 6xHis-tagged tag, molecular weight 20.1 kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Measured by its binding ability in a functional ELISA.Immobilized Human IL3RA at 2 μg/mL can bind Anti-IL3RA recombinant antibody.The EC50 is 1.254-1.412 ng/mL.;IL3RA Recombinant Monoclonal Antibody captured on Protein A Chip can bind Human IL3RA with an affinity constant of 0.202 nM as detected by MetaSPR Assay (WeSPRTM 200).

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

Protein Biology

Function

Preptin undergoes glucose-mediated co-secretion with insulin, and acts as a physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3

Gene: IGF2  |  Organism: Homo sapiens

Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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