Recombinant Human Insulin-like growth factor II (IGF2) (E30R, F43L, S63P) (Active), Homo sapiens (Human), Mammalian cell, N-terminal 6xHis-tagged, 20.1 kDa, purity >95% as determined by SDS-PAGE.
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Recombinant Human Insulin-like growth factor II (IGF2) (E30R, F43L, S63P) (Active)

Recombinant Human Insulin-like growth factor II (IGF2) (E30R, F43L, S63P) (Active) — Preptin undergoes glucose-mediated co-secretion with insulin, and acts as a physiological amplifier of glucose-mediated insulin secretion. Purity >95%.

SKU: BCACP-000596 Categories: ,
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Product SKUBCACP-000596
Product DescriptionRecombinant Human Insulin-like growth factor II (IGF2) (E30R, F43L, S63P) protein is expressed from Mammalian cell with N-terminal 6xHis-tagged. It contains 25-180aa(E30R,F43L,S63P). [Accession | P01344].
Uniprot No.P01344
Gene NamesIGF2
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region25-180aa(E30R,F43L,S63P)
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-tagged
Molecular weight20.1 kDa
ActivityMeasured by its binding ability in a functional ELISA.Immobilized Human IL3RA at 2 μg/mL can bind Anti-IL3RA recombinant antibody.The EC50 is 1.254-1.412 ng/mL.;IL3RA Recombinant Monoclonal Antibody captured on Protein A Chip can bind Human IL3RA with an affinity constant of 0.202 nM as detected by MetaSPR Assay (WeSPRTM 200).
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesInsulin-like growth factor 2; Insulin-like growth factor II; IGF-II; Somatomedin-A; T3M-11-derived growth factor [Cleaved into: Insulin-like growth factor II Ala-25 Del; Preptin]

Function

Preptin undergoes glucose-mediated co-secretion with insulin, and acts as a physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.

Product Specifications

Recombinant Human Insulin-like growth factor II (IGF2) (E30R, F43L, S63P) (Active) is a recombinant protein, expressed in Mammalian cell, covering amino acids 25-180aa(E30R,F43L,S63P), with N-terminal 6xHis-tagged tag, molecular weight 20.1 kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Preptin undergoes glucose-mediated co-secretion with insulin, and acts as a physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3

Gene: IGF2  |  Organism: Homo sapiens

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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