Recombinant Human Interferon beta (IFNB1)

Function

Type I interferon cytokine that plays a key role in the innate immune response to infection, developing tumors and other inflammatory stimuli (PubMed:10049744, PubMed:10556041, PubMed:6157094, PubMed:6171735, PubMed:7665574, PubMed:8027027, PubMed:8969169). Signals via binding to high-affinity (IFNAR2) and low-affinity (IFNAR1) heterodimeric receptor, activating the canonical Jak-STAT signaling pathway resulting in transcriptional activation or repression of interferon-regulated genes that encode the effectors of the interferon response, such as antiviral proteins, regulators of cell proliferation and differentiation, and immunoregulatory proteins (PubMed:10049744, PubMed:10556041, PubMed:7665574, PubMed:8027027, PubMed:8969169). Signals mostly via binding to a IFNAR1-IFNAR2 heterodimeric receptor, but can also function with IFNAR1 alone and independently of Jak-STAT pathways (By similarity). Elicits a wide variety of responses, including antiviral and antibacterial activities, and can regulate the development of B-cells, myelopoiesis and lipopolysaccharide (LPS)-inducible production of tumor necrosis factor (By similarity). Plays a role in neuronal homeostasis by regulating dopamine turnover and protecting dopaminergic neurons: acts by promoting neuronal autophagy and alpha-synuclein clearance, thereby preventing dopaminergic neuron loss (By similarity). IFNB1 is more potent than interferon-alpha (IFN-alpha) in inducing the apoptotic and antiproliferative pathways required for control of tumor cell growth (By similarity)

Subcellular Location

Secreted

Subunit

Monomer

• Taniguchi T. et al. The nucleotide sequence of human fibroblast interferon cDNA. — Gene (1980)
• Derynck R. et al. Isolation and structure of a human fibroblast interferon gene. — Nature (1980)
• Goeddel D.V. et al. Synthesis of human fibroblast interferon by E. coli. — Nucleic Acids Res. (1980)
• Lawn R.M. et al. Human fibroblast interferon gene lacks introns. — Nucleic Acids Res. (1981)
• Ohno S. et al. Structure of a chromosomal gene for human interferon beta. — Proc. Natl. Acad. Sci. U.S.A. (1981)
• Houghton M. et al. The complete amino acid sequence of human fibroblast interferon as deduced using synthetic oligodeoxyribonucleotide primers of reverse transcriptase. — Nucleic Acids Res. (1980)
• May L.T. et al. On the relationship between human interferon alpha 1 and beta 1 genes. — J. Interferon Res. (1985)
• Livingston R.J. et al. PubMed: CI-JGR3DF5COMGD (OCT-)