Recombinant Human Interleukin-3 receptor subunit alpha (IL3RA), partial (Active), Homo sapiens (Human), Mammalian cell, C-terminal 10xHis-tagged, 34.5 kDa, purity >90% as determined by SDS-PAGE.
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Recombinant Human Interleukin-3 receptor subunit alpha (IL3RA), partial (Active)

Recombinant Human Interleukin-3 receptor subunit alpha (IL3RA), partial (Active) — Cell surface receptor for IL3 expressed on hematopoietic progenitor cells, monocytes and B-lymphocytes that controls the production and differentiation of hematopoietic progenitor cells into lineag… Purity >90%.

SKU: BCACP-000599 Categories: ,
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Product SKUBCACP-000599
Product DescriptionRecombinant Human Interleukin-3 receptor subunit alpha (IL3RA) protein is expressed from Mammalian cell with C-terminal 10xHis-tagged. It contains 19-305aa. [Accession | P26951].
Uniprot No.P26951
Gene NamesIL3RA
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region19-305aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal 10xHis-tagged
Molecular weight34.5 kDa
ActivityMeasured by its binding ability in a functional ELISA.Immobilized Human SDC1 at 2 μg/mL can bind anti-SDC1 recombinant antibody.The EC50 is 0.7196-0.8309 ng/mL.;SDC1 Recombinant Monoclonal Antibody captured on Protein A Chip can bind Human SDC1 with an affinity constant of 6.79 nM as detected by MetaSPR Assay (WeSPRTM 200).
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesInterleukin-3 receptor subunit alpha; IL-3 receptor subunit alpha; IL-3R subunit alpha; IL-3R-alpha; IL-3RA; CD antigen CD123

Function

Cell surface receptor for IL3 expressed on hematopoietic progenitor cells, monocytes and B-lymphocytes that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells. Ligand stimulation rapidly induces hetrodimerization with IL3RB, phosphorylation and enzyme activity of effector proteins such as JAK2 and PI3K that play a role in signaling cell proliferation and differentiation. Activation of JAK2 leads to STAT5-mediated transcriptional program.

Product Specifications

Recombinant Human Interleukin-3 receptor subunit alpha (IL3RA), partial (Active) is a recombinant protein, expressed in Mammalian cell, covering amino acids 19-305aa, with C-terminal 10xHis-tagged tag, molecular weight 34.5 kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Measured by its binding ability in a functional ELISA.Immobilized Human SDC1 at 2 μg/mL can bind anti-SDC1 recombinant antibody.The EC50 is 0.7196-0.8309 ng/mL.;SDC1 Recombinant Monoclonal Antibody captured on Protein A Chip can bind Human SDC1 with an affinity constant of 6.79 nM as detected by MetaSPR Assay (WeSPRTM 200).

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Cell surface receptor for IL3 expressed on hematopoietic progenitor cells, monocytes and B-lymphocytes that controls the production and differentiation of hematopoietic progenitor cells into lineage-restricted cells (PubMed:10527461). Ligand stimulation rapidly induces hetrodimerization with IL3RB, phosphorylation and enzyme activity of effector proteins such as JAK2 and PI3K that play a role in signaling cell proliferation and differentiation. Activation of JAK2 leads to STAT5-mediated transcriptional program (By similarity)

Gene: IL3RA  |  Organism: Homo sapiens

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Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

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Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

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Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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