Recombinant Human Interleukin-4 receptor subunit alpha(IL4R), partial,Biotinylated (Active), Homo sapiens (Human), Mammalian cell, C-terminal 10xHis-Avi-tagged, 28.3 kDa, purity >95% as determined by SDS-PAGE.
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Recombinant Human Interleukin-4 receptor subunit alpha(IL4R), partial,Biotinylated (Active)

Recombinant Human Interleukin-4 receptor subunit alpha(IL4R), partial,Biotinylated (Active) — recombinant protein from Homo sapiens (Human), expressed in Mammalian cell. Purity >95%.

SKU: BCACP-000266 Categories: , , ,
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Product SKUBCACP-000266
Product DescriptionRecombinant Human Interleukin-4 receptor subunit alpha(IL4R), Biotinylated protein is expressed from Mammalian cell with C-terminal 10xHis-Avi-tagged. It contains 26-232aa. [Accession | P24394].
Uniprot No.P24394
Gene NamesIL4R
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region26-232aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal 10xHis-Avi-tagged
Molecular weight28.3 kDa
ActivityThe ED50 as determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is 58 - 295 pg/mL.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesIL4RA;582J2.1

Function

Soluble IL4R (sIL4R) inhibits IL4-mediated cell proliferation and IL5 up-regulation by T-cells.

Biological Context

Subcellular Location: Secreted
Tissue Specificity: Isoform 1 and isoform 2 are highly expressed in activated T-cells

Product Specifications

Recombinant Human Interleukin-4 receptor subunit alpha(IL4R), partial,Biotinylated (Active) is a recombinant protein from Homo sapiens (Human), expressed in Mammalian cell, covering amino acids 26-232aa, with C-terminal 10xHis-Avi-tagged tag, molecular weight 28.3 kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: The ED50 as determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is 58 - 295 pg/mL.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Soluble IL4R (sIL4R) inhibits IL4-mediated cell proliferation and IL5 up-regulation by T-cells

Subcellular Location

Secreted

Tissue Specificity

Isoform 1 and isoform 2 are highly expressed in activated T-cells

Subunit

The functional IL4 receptor is formed by initial binding of IL4 to IL4R. Subsequent recruitment to the complex of the common gamma chain, in immune cells, creates a type I receptor and, in non-immune cells, of IL13RA1 forms a type II receptor. IL4R can also interact with the IL13/IL13RA1 complex to form a similar type II receptor (PubMed:7775445, PubMed:8804422). Interacts with PIK3C3 (By similarity). Interacts with the SH2-containing phosphatases, PTPN6/SHIP1, PTPN11/SHIP2 and INPP5D/SHIP (PubMed:11714803). Interacts with JAK1 through a Box 1-containing region; inhibited by SOCS5. Interacts with SOCS5; inhibits IL4 signaling (By similarity). Interacts with JAK3 (PubMed:7538655). Interacts with CLM1 (By similarity). Interacts with IL13RA2 (PubMed:17030238)

Gene: IL4R  |  Organism: Homo sapiens
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How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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