Recombinant Human Interleukin-7 (IL7) (Active) (GMP)

Function

Hematopoietic cytokine that plays an essential role in the development, expansion, and survival of naive and memory T-cells and B-cells thereby regulating the number of mature lymphocytes and maintaining lymphoid homeostasis (PubMed:25870237, PubMed:7527823). Mechanistically, exerts its biological effects through a receptor composed of IL7RA subunit and the cytokine receptor common subunit gamma/CSF2RG (PubMed:8128231). Binding to the receptor leads to activation of various kinases including JAK1 or JAK3 depending on the cell type and subsequently propagation of signals through activation of several downstream signaling pathways including the PI3K/Akt/mTOR or the JAK-STAT5 (PubMed:18523275, PubMed:20974963)

Subcellular Location

Secreted

Disease Association

Immunodeficiency 130 with HPV-related verrucosis (IMD130) : An autosomal recessive immunologic disorder characterized by susceptibility to human papillomavirus (HPV) infections that lead to the development of warts and verrucous or plaque-like skin lesions. There is an increased risk of skin malignancy. Some patients may also suffer from mycobacterial, herpes simplex virus (HSV), or fungal infections. Immunologic workup shows T-cell lymphopenia, particularly affecting CD4+ T cells. [The disease may be caused by variants affecting the gene represented in this entry]

Subunit

Interacts with IL7R and CSF2RG

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• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). — Genome Res. (2004)
• Dittel B.N. et al. The growth response to IL-7 during normal human B cell ontogeny is restricted to B-lineage cells expressing CD34. — J. Immunol. (1995)