Recombinant Human Islet amyloid polypeptide (IAPP), partial, Homo sapiens (Human), Yeast, N-terminal 6xHis-tagged, 5.9kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Islet amyloid polypeptide (IAPP), partial

Recombinant Human Islet amyloid polypeptide (IAPP), partial — Amylin/IAPP is a glucoregulatory peptide hormone that plays an important role in the regulation of energy homeostasis. Purity >90%.

SKU: BCRECP-000877 Category:
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Product Specifications

Product SkuBCRECP-000877
Product DescriptionRecombinant Human Islet amyloid polypeptide (IAPP) Protein is expressed from Yeast with N-terminal 6xHis-tagged. It contains 34-70aa. [Accession | P10997].
Uniprot No.P10997
Gene NamesIAPP
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemYeast
Expression Region34-70aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-tagged
Molecular weight5.9kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasSignal Transduction

Function

Amylin/IAPP is a glucoregulatory peptide hormone that plays an important role in the regulation of energy homeostasis. Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. IAPP function is mediated by the CALCR-RAMPs (AMYRs) receptor complexes.

Biological Context

Subcellular Location: Secreted

Product Specifications

Recombinant Human Islet amyloid polypeptide (IAPP), partial is a recombinant protein from Homo sapiens (Human), expressed in Yeast, covering amino acids 34-70aa, with N-terminal 6xHis-tagged tag, molecular weight 5.9kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Amylin/IAPP is a glucoregulatory peptide hormone that plays an important role in the regulation of energy homeostasis (PubMed:2690069). Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. IAPP function is mediated by the CALCR-RAMPs (AMYRs) receptor complexes (By similarity). Amylin can also bind CALCR receptor in the absence of RAMPs, although it is more selective for AMYRs (By similarity)

Subcellular Location

Secreted

Subunit

Can form homodimers (PubMed:19475663). Interacts with IDE and INS (PubMed:17051221, PubMed:19475663). Interaction with INS inhibits homodimerization and fibril formation (PubMed:19475663)

Gene: IAPP  |  Organism: Homo sapiens  |  Synonyms: Amylin; Diabetes-associated peptide; Insulinoma amyloid peptide
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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