Recombinant Human Keratin, type I cytoskeletal 13 (KRT13), Homo sapiens (Human), E.coli, N-terminal 10xHis-tagged and C-terminal Myc-tagged, 57.0kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Keratin, type I cytoskeletal 13 (KRT13)

Recombinant Human Keratin, type I cytoskeletal 13 (KRT13) — Structural component of intermediate filaments in mucosal stratified squamous epithelia. Purity >90%.

SKU: BCRECP-001025 Category:
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Product Specifications

Product SkuBCRECP-001025
Product DescriptionRecombinant Human Keratin, type I cytoskeletal 13 (KRT13) Protein is expressed from E.coli with N-terminal 10xHis-tagged and C-terminal Myc-tagged. It contains 1-458aa. [Accession | P13646].
Uniprot No.P13646
Gene NamesKRT13
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region1-458aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 10xHis-tagged and C-terminal Myc-tagged
Molecular weight57.0kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasSignal Transduction

Function

Structural component of intermediate filaments in mucosal stratified squamous epithelia. Forms heteropolymers with the type II keratin KRT4, assembling into keratin intermediate filament networks that provides structural integrity and mechanical stability of the mucosal epithelium. Contributes to postnatal tongue mucosal cell homeostasis and tissue organization in response to mechanical stress, potentially through regulation of the G1/S phase cyclins CCNE1 and CCNE2.

Biological Context

Tissue Specificity: Expressed in some epidermal sweat gland ducts (at protein level) and in exocervix, esophagus and placenta
Disease Association: White sponge nevus 2 (WSN2) : A rare disorder characterized by the presence of soft, white, and spongy plaques in the oral mucosa. The characteristic histopathologic features are epithelial thickening, parakeratosis, and vacuolization of the suprabasal layer of oral epithelial keratinocytes. Less frequently the mucous membranes of the nose, esophagus, genitalia and rectum are involved. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Keratin, type I cytoskeletal 13 (KRT13) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 1-458aa, with N-terminal 10xHis-tagged and C-terminal Myc-tagged tag, molecular weight 57.0kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

Related products

Protein Biology

Function

Structural component of intermediate filaments in mucosal stratified squamous epithelia. Forms heteropolymers with the type II keratin KRT4, assembling into keratin intermediate filament networks that provides structural integrity and mechanical stability of the mucosal epithelium (PubMed:7493031). Contributes to postnatal tongue mucosal cell homeostasis and tissue organization in response to mechanical stress, potentially through regulation of the G1/S phase cyclins CCNE1 and CCNE2 (By similarity)

Disease Association

White sponge nevus 2 (WSN2) : A rare disorder characterized by the presence of soft, white, and spongy plaques in the oral mucosa. The characteristic histopathologic features are epithelial thickening, parakeratosis, and vacuolization of the suprabasal layer of oral epithelial keratinocytes. Less frequently the mucous membranes of the nose, esophagus, genitalia and rectum are involved. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Expressed in some epidermal sweat gland ducts (at protein level) and in exocervix, esophagus and placenta

Subunit

Heterodimers composed of one type I and one type II keratins; forms parallel coiled-coil heterodimers. Heterodimers associate in an antiparallel manner to form heterotetramers, which further assemble into higher-order keratin intermediate filaments

Gene: KRT13  |  Organism: Homo sapiens  |  Synonyms: Cytokeratin-13; Keratin-13
Key Publications

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How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

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Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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