Recombinant Human Keratin,type II cytoskeletal 8 (KRT8), partial, Homo sapiens (Human), E.coli, N-terminal 6xHis-SUMO-tagged, 66.5kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Keratin,type II cytoskeletal 8 (KRT8), partial

Recombinant Human Keratin,type II cytoskeletal 8 (KRT8), partial — Structural component of intermediate filaments in simple epithelial cells. Purity >90%.

SKU: BCRECP-001044 Category:
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Product Specifications

Product SkuBCRECP-001044
Product DescriptionRecombinant Human Keratin,type II cytoskeletal 8 (KRT8) Protein is expressed from E.coli with N-terminal 6xHis-SUMO-tagged. It contains 2-483aa. [Accession | P05787].
Uniprot No.P05787
Gene NamesKRT8
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region2-483aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-SUMO-tagged
Molecular weight66.5kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasImmunology

Function

Structural component of intermediate filaments in simple epithelial cells. Together with its obligate type I partner KRT18, contributes to the formation of the keratin intermediate filament network that provides mechanical stability and resilience to epithelial cells. Also involved in maintaining epithelial integrity and protecting cells from non-mechanical stress, such as apoptosis.

Biological Context

Subcellular Location: Cytoplasm; Nucleus, nucleoplasm; Nucleus matrix; Cytoplasm, cytoskeleton
Tissue Specificity: Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity

Product Specifications

Recombinant Human Keratin,type II cytoskeletal 8 (KRT8), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 2-483aa, with N-terminal 6xHis-SUMO-tagged tag, molecular weight 66.5kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Structural component of intermediate filaments in simple epithelial cells. Together with its obligate type I partner KRT18, contributes to the formation of the keratin intermediate filament network that provides mechanical stability and resilience to epithelial cells (PubMed:26823019). Also involved in maintaining epithelial integrity and protecting cells from non-mechanical stress, such as apoptosis (By similarity). Also required for ARHGEF40-mediated actin stress fiber formation and tensional force-induced stress fiber formation and reinforcement (PubMed:26823019). In striated muscle, together with KRT19, may contribute to linking the contractile apparatus to dystrophin at the costameres (PubMed:16000376)

Subcellular Location

Cytoplasm; Nucleus, nucleoplasm; Nucleus matrix; Cytoplasm, cytoskeleton

Tissue Specificity

Observed in muscle fibers accumulating in the costameres of myoplasm at the sarcolemma membrane in structures that contain dystrophin and spectrin. Expressed in gingival mucosa and hard palate of the oral cavity

Subunit

(Microbial infection) Interacts with hepatitis C virus/HCV core protein

Gene: KRT8  |  Organism: Homo sapiens  |  Synonyms: Cytokeratin-8; Keratin-8; Type-II keratin Kb8
Key Publications

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How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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