Recombinant Human Kinesin-like protein KIF18B (KIF18B), partial, Homo sapiens (Human), E.coli, N-terminal 10xHis-tagged and C-terminal Myc-tagged, 46.9kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Kinesin-like protein KIF18B (KIF18B), partial

Recombinant Human Kinesin-like protein KIF18B (KIF18B), partial — In complex with KIF2C, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Purity >90%.

SKU: BCRECP-001006 Category:
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Product Specifications

Product SkuBCRECP-001006
Product DescriptionRecombinant Human Kinesin-like protein KIF18B (KIF18B) Protein is expressed from E.coli with N-terminal 10xHis-tagged and C-terminal Myc-tagged. It contains 1-355aa. [Accession | Q86Y91].
Uniprot No.Q86Y91
Gene NamesKIF18B
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region1-355aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 10xHis-tagged and C-terminal Myc-tagged
Molecular weight46.9kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasCell Biology

Function

In complex with KIF2C, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Its major role may be to transport KIF2C and/or MAPRE1 along microtubules.

Biological Context

Subcellular Location: Nucleus; Cytoplasm; Cytoplasm, cytoskeleton
Tissue Specificity: Shows a prominent expression in the amygdala

Product Specifications

Recombinant Human Kinesin-like protein KIF18B (KIF18B), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 1-355aa, with N-terminal 10xHis-tagged and C-terminal Myc-tagged tag, molecular weight 46.9kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

In complex with KIF2C, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells. Its major role may be to transport KIF2C and/or MAPRE1 along microtubules

Subcellular Location

Nucleus; Cytoplasm; Cytoplasm, cytoskeleton

Tissue Specificity

Shows a prominent expression in the amygdala

Subunit

Interacts with MAPRE1; this interaction is required for efficient accumulation at microtubule plus ends. Interacts with KIF2C at microtubule tips; this interaction increases the affinity of both partners for microtubule plus ends and is required for robust microtubule depolymerization. KIF2C phosphorylation by AURKA or AURKB strongly reduces KIF18B-binding

Gene: KIF18B  |  Organism: Homo sapiens
Key Publications

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How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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