Recombinant Human Leucine-rich glioma-inactivated protein 1 (LGI1), partial, Homo sapiens (Human), E.coli, N-terminal 10xHis-tagged and C-terminal Myc-tagged, 46.3kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Leucine-rich glioma-inactivated protein 1 (LGI1), partial

Recombinant Human Leucine-rich glioma-inactivated protein 1 (LGI1), partial — Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. Purity >90%.

SKU: BCRECP-001062 Category:
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Product Specifications

Product SkuBCRECP-001062
Product DescriptionRecombinant Human Leucine-rich glioma-inactivated protein 1 (LGI1) Protein is expressed from E.coli with N-terminal 10xHis-tagged and C-terminal Myc-tagged. It contains 224-557aa. [Accession | O95970].
Uniprot No.O95970
Gene NamesLGI1
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region224-557aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 10xHis-tagged and C-terminal Myc-tagged
Molecular weight46.3kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasSignal Transduction

Function

Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors.

Biological Context

Subcellular Location: Endoplasmic reticulum; Cytoplasm
Tissue Specificity: Abundantly expressed in the occipital cortex and weakly expressed in the hippocampus (at protein level)
Disease Association: Epilepsy, familial temporal lobe, 1 (ETL1) : A focal form of epilepsy characterized by recurrent seizures that arise from foci within the temporal lobe. Seizures are usually accompanied by sensory symptoms, most often auditory in nature. [The disease is caused by variants affecting the gene represented in this entry] | Developmental and epileptic encephalopathy 121 (DEE121) : A form of epileptic encephalopathy, a heterogeneous group of early-onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. DEE121 is an autosomal recessive form characterized by neonatal- or infantile-onset epilepsy, global developmental delay or intellectual disability. Death in infancy, childhood, or early adulthood is frequent. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Leucine-rich glioma-inactivated protein 1 (LGI1), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 224-557aa, with N-terminal 10xHis-tagged and C-terminal Myc-tagged tag, molecular weight 46.3kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

Related products

Protein Biology

Function

Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors (By similarity). Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway (PubMed:15047712)

Subcellular Location

Endoplasmic reticulum; Cytoplasm

Disease Association

Epilepsy, familial temporal lobe, 1 (ETL1) : A focal form of epilepsy characterized by recurrent seizures that arise from foci within the temporal lobe. Seizures are usually accompanied by sensory symptoms, most often auditory in nature. [The disease is caused by variants affecting the gene represented in this entry] | Developmental and epileptic encephalopathy 121 (DEE121) : A form of epileptic encephalopathy, a heterogeneous group of early-onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. DEE121 is an autosomal recessive form characterized by neonatal- or infantile-onset epilepsy, global developmental delay or intellectual disability. Death in infancy, childhood, or early adulthood is frequent. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Abundantly expressed in the occipital cortex and weakly expressed in the hippocampus (at protein level)

Subunit

Oligomer. Interacts with KCNA1 within a complex containing KCNA1, KCNA4 and KCNAB1. Part of a complex containing ADAM22, DLG4/PSD95 and CACNG2/Stargazin (PubMed:27066583). Can bind to ADAM11 and ADAM23 (By similarity)

Gene: LGI1  |  Organism: Homo sapiens  |  Synonyms: Epitempin-1
Key Publications

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