Recombinant Human Leucine-rich repeat-containing G-protein coupled receptor 6 (LGR6), partial, Homo sapiens (Human), E.coli, C-terminal 6xHis-tagged, 61.6kDa, purity >85% as determined by SDS-PAGE.

Recombinant Human Leucine-rich repeat-containing G-protein coupled receptor 6 (LGR6), partial

Recombinant Human Leucine-rich repeat-containing G-protein coupled receptor 6 (LGR6), partial — Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a marker of multipotent stem cells in the epidermis. Purity >85%.

SKU: BCRECP-001066 Category:
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Product Specifications

Product SkuBCRECP-001066
Product DescriptionRecombinant Human Leucine-rich repeat-containing G-protein coupled receptor 6 (LGR6) Protein is expressed from E.coli with C-terminal 6xHis-tagged. It contains 25-567aa. [Accession | Q9HBX8].
Uniprot No.Q9HBX8
Gene NamesLGR6
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region25-567aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal 6xHis-tagged
Molecular weight61.6kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasSignal Transduction

Function

Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a marker of multipotent stem cells in the epidermis. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G protein-coupled receptors, does not activate heterotrimeric G proteins to transduce the signal.

Biological Context

Subcellular Location: Cell membrane (Multi-pass membrane protein)

Product Specifications

Recombinant Human Leucine-rich repeat-containing G-protein coupled receptor 6 (LGR6), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 25-567aa, with C-terminal 6xHis-tagged tag, molecular weight 61.6kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a marker of multipotent stem cells in the epidermis. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G protein-coupled receptors, does not activate heterotrimeric G proteins to transduce the signal. May act as a tumor suppressor

Subcellular Location

Cell membrane (Multi-pass membrane protein)

Gene: LGR6  |  Organism: Homo sapiens
Key Publications

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Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

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Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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