Recombinant Human Low affinity immunoglobulin epsilon Fc receptor (FCER2), partial, Homo sapiens (Human), E.coli, N-terminal 6xHis-tagged, 27.3kDa, purity >90% as determined by SDS-PAGE.
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Recombinant Human Low affinity immunoglobulin epsilon Fc receptor (FCER2), partial

Recombinant Human Low affinity immunoglobulin epsilon Fc receptor (FCER2), partial — Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Purity >90%.

SKU: BCRECP-000645 Categories: ,
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Product Specifications

Product SkuBCRECP-000645
Product DescriptionRecombinant Human Low affinity immunoglobulin epsilon Fc receptor (FCER2) Protein is expressed from E.coli with N-terminal 6xHis-tagged. It contains 48-248aa. [Accession | P06734].
Uniprot No.P06734
Gene NamesFCER2
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region48-248aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-tagged
Molecular weight27.3kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasImmunology

Function

Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B cells. On B cells, initiates IgE-dependent antigen uptake and presentation to T cells.

Biological Context

Subcellular Location: Cell membrane (Single-pass type II membrane protein); Cell membrane (Lipid-anchor); Secreted
Tissue Specificity: Detected in urine (at protein level)

Product Specifications

Recombinant Human Low affinity immunoglobulin epsilon Fc receptor (FCER2), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 48-248aa, with N-terminal 6xHis-tagged tag, molecular weight 27.3kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

Related products

Protein Biology

Function

Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B cells. On B cells, initiates IgE-dependent antigen uptake and presentation to T cells (PubMed:2167225). On macrophages, upon IgE binding and antigen cross-linking induces intracellular killing of parasites through activation of L-Arginine-nitric oxide pathway (PubMed:7544003)

Subcellular Location

Cell membrane (Single-pass type II membrane protein); Cell membrane (Lipid-anchor); Secreted

Tissue Specificity

Detected in urine (at protein level)

Subunit

Homotrimer. Interacts (via C-type lectin domain) with IGHE (via CH3 region); this interaction regulates IgE homeostasis. Interacts (via the C-terminus) with CR2/CD21 (via Sushi domain 1 and 2) (PubMed:1386409, PubMed:16172256)

Gene: FCER2  |  Organism: Homo sapiens  |  Synonyms: BLAST-2; C-type lectin domain family 4 member J; Fc-epsilon-RII; Immunoglobulin E-binding factor; Lymphocyte IgE receptor
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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