Recombinant Human Low affinity immunoglobulin gamma Fc region receptor III-A (FCGR3A) (F176V), partial (Active)

Function

(Microbial infection) Involved in Dengue virus pathogenesis via antibody-dependent enhancement (ADE) mechanism. Secondary infection with Dengue virus triggers elevated levels of afucosylated non-neutralizing IgG1s with reactivity to viral envelope/E protein. Viral antigen-IgG1 complexes bind with high affinity to FCGR3A, facilitating virus entry in myeloid cells and subsequent viral replication

Subcellular Location

Cell membrane (Single-pass type I membrane protein); Secreted

Disease Association

Immunodeficiency 20 (IMD20) : A rare autosomal recessive primary immunodeficiency characterized by functional deficiency of NK cells. Affected individuals typically present with severe herpes viral infections, particularly Epstein Barr virus (EBV), and human papillomavirus (HPV). [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Expressed in natural killer cells (at protein level) (PubMed:2526846). Expressed in a subset of circulating monocytes (at protein level) (PubMed:27670158)

Subunit

Forms a heterooligomeric complex with ITAM-containing signaling subunits, either a homodimer of CD247, a homodimer of FCER1G or a heterodimer of CD247 and FCER1G (PubMed:1825220, PubMed:2532305, PubMed:28652325). Interacts (via transmembrane domain) with signaling subunits; this interaction is a prerequisite for receptor complex expression on the cell surface and intracellular signal transduction (PubMed:1825220, PubMed:2532305, PubMed:28652325). Binds the Fc region of antigen-complexed IgG with a preference for IgG1 and IgG3 isotypes (PubMed:11711607, PubMed:21768335, PubMed:22023369, PubMed:8609432, PubMed:9242542, PubMed:28566370, PubMed:37421619, PubMed:30061887). Interacts with CD2; this interaction is involved in NK cell activation and cytotoxicity (PubMed:23006327). Interacts with S100A4; this interaction inhibits PKC-dependent phosphorylation of FCGR3A (PubMed:23024279)

• Ravetch J.V. et al. Alternative membrane forms of Fc gamma RIII(CD16) on human natural killer cells and neutrophils. Cell type-specific expression of two genes that differ in single nucleotide substitutions. — J. Exp. Med. (1989)
• Rogers K.A. et al. IgG Fc receptor III homologues in nonhuman primate species: genetic characterization and ligand interactions. — J. Immunol. (2006)
• Suzuki Y. et al. PubMed: CI-5AVBODINQ93DF (APR-)
• Gregory S.G. et al. The DNA sequence and biological annotation of human chromosome 1. — Nature (2006)
• The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). — Genome Res. (2004)
• Gessner J.E. et al. The human low affinity immunoglobulin G Fc receptor III-A and III-B genes. Molecular characterization of the promoter regions. — J. Biol. Chem. (1995)
• Morcos M. et al. Human glomerular mesangial cells express CD16 and may be stimulated via this receptor. — Kidney Int. (1994)
• Scallon B.J. et al. A human immunoglobulin G receptor exists in both polypeptide-anchored and phosphatidylinositol-glycan-anchored forms. — Proc. Natl. Acad. Sci. U.S.A. (1989)