Recombinant Human Low affinity immunoglobulin gamma Fc region receptor III-B (FCGR3B), Homo sapiens (Human), E.coli, C-terminal 6xHis-tagged, 24.9kDa, purity >90% as determined by SDS-PAGE.
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Recombinant Human Low affinity immunoglobulin gamma Fc region receptor III-B (FCGR3B)

Recombinant Human Low affinity immunoglobulin gamma Fc region receptor III-B (FCGR3B) — Receptor for the Fc region of immunoglobulins gamma. Purity >90%.

SKU: BCRECP-000652 Categories: ,
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Product Specifications

Product SkuBCRECP-000652
Product DescriptionRecombinant Human Low affinity immunoglobulin gamma Fc region receptor III-B (FCGR3B) Protein is expressed from E.coli with C-terminal 6xHis-tagged. It contains 17-200aa. [Accession | O75015].
Uniprot No.O75015
Gene NamesFCGR3B
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region17-200aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal 6xHis-tagged
Molecular weight24.9kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasImmunology

Function

Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG.

Biological Context

Subcellular Location: Cell membrane (Lipid-anchor, GPI-anchor); Secreted
Tissue Specificity: Expressed specifically by polymorphonuclear leukocytes (neutrophils). Also expressed by stimulated eosinophils

Product Specifications

Recombinant Human Low affinity immunoglobulin gamma Fc region receptor III-B (FCGR3B) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 17-200aa, with C-terminal 6xHis-tagged tag, molecular weight 24.9kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils

Subcellular Location

Cell membrane (Lipid-anchor, GPI-anchor); Secreted

Tissue Specificity

Expressed specifically by polymorphonuclear leukocytes (neutrophils). Also expressed by stimulated eosinophils

Subunit

Monomer. Interacts with INPP5D/SHIP1 (By similarity). Interacts with the Fc region of IgGs with a preference for IgG1 and IgG3 isotypes

Gene: FCGR3B  |  Organism: Homo sapiens  |  Synonyms: Fc-gamma RIII-beta; FcR-10; IgG Fc receptor III-1
Key Publications

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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