Recombinant Human Lupus La protein (SSB), Homo sapiens (Human), E.coli, N-terminal 6xHis-SUMO-tagged, 62.8kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Lupus La protein (SSB)

Recombinant Human Lupus La protein (SSB) — Binds to the 3′ poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation. Purity >90%.

SKU: BCRECP-001699 Category:
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Product Specifications

Product SkuBCRECP-001699
Product DescriptionRecombinant Human Lupus La protein (SSB) Protein is expressed from E.coli with N-terminal 6xHis-SUMO-tagged. It contains 1-408aa. [Accession | P05455].
Uniprot No.P05455
Gene NamesSSB
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region1-408aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-SUMO-tagged
Molecular weight62.8kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasEpigenetics and Nuclear Signaling

Function

Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation. In case of Coxsackievirus B3 infection, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation.

Biological Context

Subcellular Location: Nucleus

Product Specifications

Recombinant Human Lupus La protein (SSB) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 1-408aa, with N-terminal 6xHis-SUMO-tagged tag, molecular weight 62.8kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation (PubMed:2470590, PubMed:3192525). In case of Coxsackievirus B3 infection, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12384597)

Subcellular Location

Nucleus

Subunit

Interacts with DDX15. May interact with RUFY1

Gene: SSB  |  Organism: Homo sapiens  |  Synonyms: La autoantigen; La ribonucleoprotein; Sjoegren syndrome type B antigen
Key Publications

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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