Function
G protein-coupled photoreceptor that selectively activates G(i) proteins in response to medium-wavelength (green) light, thereby decreasing intracellular cAMP levels. Activation occurs when the opsin-bound cis-retinal chromophore absorbs a photon and isomerizes to all-trans-retinal, inducing a conformational change in the opsin that triggers a G protein-mediated phototransduction cascade (Ref.6). Mediates visual perception of green light in cone photoreceptor cells.
Biological Context
Subcellular Location: Cell membrane (Multi-pass membrane protein); Photoreceptor outer segment membrane (Multi-pass membrane protein)
Tissue Specificity: The red (OPN1LW), green (OPN1MW), and blue (OPN1SW) photoreceptor pigments are found in cone cells
Disease Association: Colorblindness, partial, deutan series (CBD) : An X-linked color vision defect characterized by a dichromasy in which red and green are confused, without loss of luminance or shift or shortening of the spectrum. Dichromasy is due to the use of only two types of photoreceptors, blue plus red in deuteranopia and blue plus green in protanopia. [The disease is caused by variants affecting the gene represented in this entry] | Blue cone monochromacy (BCM) : A rare X-linked congenital stationary cone dysfunction syndrome characterized by the absence of functional long wavelength-sensitive and medium wavelength-sensitive cones in the retina. Color discrimination is severely impaired from birth, and vision is derived from the remaining preserved blue (S) cones and rod photoreceptors. BCM typically presents with reduced visual acuity, pendular nystagmus, and photophobia. Patients often have myopia. [The disease is caused by variants affecting the gene represented in this entry] | Cone dystrophy 5 (COD5) : An X-linked cone dystrophy. Cone dystrophies are retinal dystrophies characterized by progressive degeneration of the cone photoreceptors with preservation of rod function, as indicated by electroretinogram. However, some rod involvement may be present in some cone dystrophies, particularly at late stage. Affected individuals suffer from photophobia, loss of visual acuity, color vision and central visual field. Another sign is the absence of macular lesions for many years. Cone dystrophies are distinguished from the cone-rod dystrophies in which some loss of peripheral vision also occurs. [The disease is caused by variants affecting the gene represented in this entry]
Product Specifications
Recombinant Human Medium-wave-sensitive opsin 1 (OPN1MW) Protein is a recombinant protein from Homo sapiens (Human), expressed in in vitro E.coli expression system, covering amino acids 1-364aa, with N-terminal 10xHis-tagged tag, molecular weight 46.6kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.
