Recombinant Human MHC class I polypeptide-related sequence A (MICA), partial (Active), Homo sapiens (Human), Mammalian cell, C-terminal 10xHis-tagged, 34.4 kDa, purity >95% as determined by SDS-PAGE.

Recombinant Human MHC class I polypeptide-related sequence A (MICA), partial (Active)

Recombinant Human MHC class I polypeptide-related sequence A (MICA), partial (Active) — Widely expressed membrane-bound protein which acts as a ligand to stimulate an activating receptor KLRK1/NKG2D, expressed on the surface of essentially all human natural killer (NK), gammadelta T a… Purity >…

SKU: BCACP-000477 Category:
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Product SKUBCACP-000477
Product DescriptionRecombinant Human MHC class I polypeptide-related sequence A (MICA) protein is expressed from Mammalian cell with C-terminal 10xHis-tagged. It contains 24-307aa. [Accession | Q29983].
Uniprot No.Q29983
Gene NamesMICA
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region24-307aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal 10xHis-tagged
Molecular weight34.4 kDa
ActivityMeasured by its binding ability in a functional ELISA. Immobilized Human TNFSF10 at 4 μg/mL can bind Human TNFRSF10B . The EC50 is 3.897-5.215 ng/mL.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative NamesMHC class I polypeptide-related sequence A; MIC-A

Function

Widely expressed membrane-bound protein which acts as a ligand to stimulate an activating receptor KLRK1/NKG2D, expressed on the surface of essentially all human natural killer (NK), gammadelta T and CD8 alphabeta T-cells. Up-regulated in stressed conditions, such as viral and bacterial infections or DNA damage response, serves as signal of cellular stress, and engagement of KLRK1/NKG2D by MICA triggers NK-cells resulting in a range of immune effector functions, such as cytotoxicity and cytokine production.

Product Specifications

Recombinant Human MHC class I polypeptide-related sequence A (MICA), partial (Active) is a recombinant protein, expressed in Mammalian cell, covering amino acids 24-307aa, with C-terminal 10xHis-tagged tag, molecular weight 34.4 kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Measured by its binding ability in a functional ELISA. Immobilized Human TNFSF10 at 4 μg/mL can bind Human TNFRSF10B . The EC50 is 3.897-5.215 ng/mL.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Widely expressed membrane-bound protein which acts as a ligand to stimulate an activating receptor KLRK1/NKG2D, expressed on the surface of essentially all human natural killer (NK), gammadelta T and CD8 alphabeta T-cells (PubMed:11491531, PubMed:11777960). Up-regulated in stressed conditions, such as viral and bacterial infections or DNA damage response, serves as signal of cellular stress, and engagement of KLRK1/NKG2D by MICA triggers NK-cells resulting in a range of immune effector functions, such as cytotoxicity and cytokine production (PubMed:10426993)

Gene: MICA  |  Organism: Homo sapiens

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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