Function
May play a role in hematopoiesis. In the cardiovascular system, could regulate growth factors or participate in cell signaling in maintaining large vessel integrity. Component of the elastin-associated microfibrils.
Biological Context
Subcellular Location: Secreted, extracellular space, extracellular matrix
Disease Association: Aortic aneurysm, familial thoracic 9 (AAT9) : A disease characterized by permanent dilation of the thoracic aorta usually due to degenerative changes in the aortic wall. It is primarily associated with a characteristic histologic appearance known as 'medial necrosis' or 'Erdheim cystic medial necrosis' in which there is degeneration and fragmentation of elastic fibers, loss of smooth muscle cells, and an accumulation of basophilic ground substance. [The disease is caused by variants affecting the gene represented in this entry]
Product Specifications
Recombinant Human Microfibrillar-associated protein 5 (MFAP5) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 22-173aa, with N-terminal 6xHis-SUMO-tagged tag, molecular weight 33.3kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.
