Recombinant Human Microtubule-associated protein tau (MAPT) (Active), Homo sapiens (Human), Mammalian cell, N-terminal 10xHis-tagged, 49.5 kDa, purity >95% as determined by SDS-PAGE.

Recombinant Human Microtubule-associated protein tau (MAPT) (Active)

Recombinant Human Microtubule-associated protein tau (MAPT) (Active) — Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. Purity >95%.

SKU: BCACP-000203 Category:
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Product SKUBCACP-000203
Product DescriptionRecombinant Human Microtubule-associated protein tau (MAPT) protein is expressed from Mammalian cell with N-terminal 10xHis-tagged. It contains 1-441aa. [Accession | P10636].
Uniprot No.P10636
Gene NamesMAPT
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region1-441aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 10xHis-tagged
Molecular weight49.5 kDa
ActivityMeasured by its binding ability in a functional ELISA. Immobilized Human SLC39A6 at 1 μg/mL can bind Anti- SLC39A6 recombinant antibody , the EC50 is 0.6873-0.9010 ng/mL.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative Names(Neurofibrillary tangle protein)(Paired helical filament-tau)(PHF-tau)

Function

Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome.

Product Specifications

Recombinant Human Microtubule-associated protein tau (MAPT) (Active) is a recombinant protein, expressed in Mammalian cell, covering amino acids 1-441aa, with N-terminal 10xHis-tagged tag, molecular weight 49.5 kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Measured by its binding ability in a functional ELISA. Immobilized Human SLC39A6 at 1 μg/mL can bind Anti- SLC39A6 recombinant antibody , the EC50 is 0.6873-0.9010 ng/mL.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity (PubMed:21985311). The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both (PubMed:21985311, PubMed:32961270). Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization

Gene: MAPT  |  Organism: Homo sapiens

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Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

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Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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