Recombinant Human Mitochondrial ornithine transporter 1 (SLC25A15), Homo sapiens (Human), E.coli, N-terminal GST-tagged, 59.7kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Mitochondrial ornithine transporter 1 (SLC25A15)

Recombinant Human Mitochondrial ornithine transporter 1 (SLC25A15) — Mitochondrial ornithine-citrulline antiporter (Probable). Purity >90%.

SKU: BCRECP-001646 Category:
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Product Specifications

Product SkuBCRECP-001646
Product DescriptionRecombinant Human Mitochondrial ornithine transporter 1 (SLC25A15) Protein is expressed from E.coli with N-terminal GST-tagged. It contains 1-301aa. [Accession | Q9Y619].
Uniprot No.Q9Y619
Gene NamesSLC25A15
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region1-301aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal GST-tagged
Molecular weight59.7kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasOthers

Function

Mitochondrial ornithine-citrulline antiporter (Probable). Catalyzes the exchange between cytosolic ornithine and mitochondrial citrulline plus an H(+), the proton compensates the positive charge of ornithine thus leading to an electroneutral transport. Plays a crucial role in the urea cycle, by connecting the cytosolic and the intramitochondrial reactions of the urea cycle (Probable).

Biological Context

Subcellular Location: Mitochondrion inner membrane (Multi-pass membrane protein); Mitochondrion membrane (Multi-pass membrane protein)
Tissue Specificity: Highly expressed in liver, pancreas, testis, lung and small intestine. Lower levels are detected in spleen, kidney, brain and heart
Disease Association: Hyperornithinemia-hyperammonemia-homocitrullinuria syndrome (HHHS) : An autosomal recessive disorder of the urea cycle characterized by onset in early life. The acute phase of the disease is characterized by vomiting, ataxia, lethargy, confusion, and coma. Chronic clinical manifestations include hypotonia, developmental delay, progressive encephalopathy with mental regression, and spastic paraparesis with pyramidal signs. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Mitochondrial ornithine transporter 1 (SLC25A15) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 1-301aa, with N-terminal GST-tagged tag, molecular weight 59.7kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

Related products

Protein Biology

Function

Mitochondrial ornithine-citrulline antiporter (Probable) (PubMed:12807890, PubMed:22262851). Catalyzes the exchange between cytosolic ornithine and mitochondrial citrulline plus an H(+), the proton compensates the positive charge of ornithine thus leading to an electroneutral transport. Plays a crucial role in the urea cycle, by connecting the cytosolic and the intramitochondrial reactions of the urea cycle (Probable) (PubMed:12807890, PubMed:22262851). Lysine and arginine are also transported by the antiport mechanism (Probable) (PubMed:12807890). In addition, catalyzes an electroneutral exchange of ornithine or lysine for H(+), a reaction driven by the pH gradient across the inner membrane (By similarity)

Subcellular Location

Mitochondrion inner membrane (Multi-pass membrane protein); Mitochondrion membrane (Multi-pass membrane protein)

Disease Association

Hyperornithinemia-hyperammonemia-homocitrullinuria syndrome (HHHS) : An autosomal recessive disorder of the urea cycle characterized by onset in early life. The acute phase of the disease is characterized by vomiting, ataxia, lethargy, confusion, and coma. Chronic clinical manifestations include hypotonia, developmental delay, progressive encephalopathy with mental regression, and spastic paraparesis with pyramidal signs. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Highly expressed in liver, pancreas, testis, lung and small intestine. Lower levels are detected in spleen, kidney, brain and heart

Gene: SLC25A15  |  Organism: Homo sapiens  |  Synonyms: Solute carrier family 25 member 15
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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