Recombinant Human Mucin-16 (MUC16), partial (Active), Homo sapiens (Human), Mammalian cell, C-terminal 6xHis-tagged, 30.5 kDa, purity >95% as determined by SDS-PAGE.

Recombinant Human Mucin-16 (MUC16), partial (Active)

Recombinant Human Mucin-16 (MUC16), partial (Active) — recombinant protein from Homo sapiens (Human), expressed in Mammalian cell. Purity >95%.

SKU: BCACP-000102 Category:
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Product SKUBCACP-000102
Product DescriptionRecombinant Human Mucin-16 (MUC16) protein is expressed from Mammalian cell with C-terminal 6xHis-tagged. It contains 12660-12923aa. [Accession | Q8WXI7].
Uniprot No.Q8WXI7
Gene NamesMUC16
PurityGreater than 95% as determined by SDS-PAGE.
Expression SystemMammalian cell
Expression Region12660-12923aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal 6xHis-tagged
Molecular weight30.5 kDa
ActivityMeasured by its binding ability in a functional ELISA. Immobilized TNF-α at 5 μg/ml can bind human TNFR1, the EC50 is 7.799-10.90 ng/ml.;Measured by its binding ability in a functional ELISA. Immobilized LTA at 5 μg/ml can bind human TNFR1, the EC50 is 4.409-6.797 ng/ml.
BufferLyophilized from a 0.2 μm filtered 20 mM Tris-HCl, 0.5 M NaCl, 6% Trehalose, pH 8.0
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Alternative Names(MUC-16)(Ovarian cancer-related tumor marker CA125)(CA-125)(CA125)

Function

Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces.

Biological Context

Subcellular Location: Cell membrane (Single-pass type I membrane protein); Secreted, extracellular space
Tissue Specificity: Expressed in corneal and conjunctival epithelia (at protein level). Overexpressed in ovarian carcinomas and ovarian low malignant potential (LMP) tumors as compared to the expression in normal ovarian tissue and ovarian adenomas

Product Specifications

Recombinant Human Mucin-16 (MUC16), partial (Active) is a recombinant protein from Homo sapiens (Human), expressed in Mammalian cell, covering amino acids 12660-12923aa, with C-terminal 6xHis-tagged tag, molecular weight 30.5 kDa, purity Greater than 95% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Measured by its binding ability in a functional ELISA. Immobilized TNF-α at 5 μg/ml can bind human TNFR1, the EC50 is 7.799-10.90 ng/ml.;Measured by its binding ability in a functional ELISA. Immobilized LTA at 5 μg/ml can bind human TNFR1, the EC50 is 4.409-6.797 ng/ml.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces

Subcellular Location

Cell membrane (Single-pass type I membrane protein); Secreted, extracellular space

Tissue Specificity

Expressed in corneal and conjunctival epithelia (at protein level). Overexpressed in ovarian carcinomas and ovarian low malignant potential (LMP) tumors as compared to the expression in normal ovarian tissue and ovarian adenomas

Subunit

Binds to MSLN. Binding to MSLN mediates heterotypic cell adhesion. This may contribute to the metastasis of ovarian cancer to the peritoneum by initiating cell attachment to the mesothelial epithelium via binding to MSLN

Gene: MUC16  |  Organism: Homo sapiens  |  Synonyms: Ovarian cancer-related tumor marker CA125; Ovarian carcinoma antigen CA125
Key Publications

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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