Recombinant Human N (G),N (G)-dimethylarginine dimethylaminohydrolase 2 (DDAH2), Homo sapiens (Human), E.coli, N-terminal 6xHis-GST-tagged, 61.2kDa, purity >85% as determined by SDS-PAGE.
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Recombinant Human N (G),N (G)-dimethylarginine dimethylaminohydrolase 2 (DDAH2)

Recombinant Human N (G),N (G)-dimethylarginine dimethylaminohydrolase 2 (DDAH2) — Putative hydrolase with unknown substrate (Probable). Purity >85%.

SKU: BCRECP-000486 Categories: ,
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Product Specifications

Product SkuBCRECP-000486
Product DescriptionRecombinant Human N (G) Protein is expressed from E.coli with N-terminal 6xHis-GST-tagged. It contains 1-285aa. [Accession | O95865].
Uniprot No.O95865
Gene NamesDDAH2
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region1-285aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 6xHis-GST-tagged
Molecular weight61.2kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasNeuroscience

Function

Putative hydrolase with unknown substrate (Probable). Does not hydrolyze N(G),N(G)-dimethyl-L-arginine (ADMA) which acts as an inhibitor of NOS. In endothelial cells, induces expression of vascular endothelial growth factor (VEGF) via phosphorylation of the transcription factor SP1 by PKA in a process that is independent of NO and NO synthase.

Biological Context

Subcellular Location: Mitochondrion
Tissue Specificity: Detected in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas, and at very low levels in brain

Product Specifications

Recombinant Human N (G),N (G)-dimethylarginine dimethylaminohydrolase 2 (DDAH2) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 1-285aa, with N-terminal 6xHis-GST-tagged tag, molecular weight 61.2kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Putative hydrolase with unknown substrate (Probable). Does not hydrolyze N(G),N(G)-dimethyl-L-arginine (ADMA) which acts as an inhibitor of NOS (PubMed:21493890, PubMed:37296100). In endothelial cells, induces expression of vascular endothelial growth factor (VEGF) via phosphorylation of the transcription factor SP1 by PKA in a process that is independent of NO and NO synthase (By similarity). Similarly, enhances pancreatic insulin secretion through SP1-mediated transcriptional up-regulation of secretagogin/SCGN, an insulin vesicle docking protein (By similarity). Upon viral infection, relocates to mitochondria where it promotes mitochondrial fission through activation of DNM1L leading to the inhibition of innate response activation mediated by MAVS (PubMed:33850055)

Subcellular Location

Mitochondrion

Tissue Specificity

Detected in heart, placenta, lung, liver, skeletal muscle, kidney and pancreas, and at very low levels in brain

Gene: DDAH2  |  Organism: Homo sapiens  |  Synonyms: DDAHII; Inactive N(G),N(G)-dimethylarginine dimethylaminohydrolase 2; Protein G6a; S-phase protein
Key Publications

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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