Recombinant Human Neurogenin-3 (NEUROG3), Homo sapiens (Human), E.coli, N-terminal 10xHis-tagged and C-terminal Myc-tagged, 30.6kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Neurogenin-3 (NEUROG3)

Recombinant Human Neurogenin-3 (NEUROG3) — Is a transcriptional regulator involved in the control of enteroendocrine cell differentiation. Purity >90%.

SKU: BCRECP-001237 Category:
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Product Specifications

Product SkuBCRECP-001237
Product DescriptionRecombinant Human Neurogenin-3 (NEUROG3) Protein is expressed from E.coli with N-terminal 10xHis-tagged and C-terminal Myc-tagged. It contains 1-214aa. [Accession | Q9Y4Z2].
Uniprot No.Q9Y4Z2
Gene NamesNEUROG3
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region1-214aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 10xHis-tagged and C-terminal Myc-tagged
Molecular weight30.6kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasEpigenetics and Nuclear Signaling

Function

Is a transcriptional regulator involved in the control of enteroendocrine cell differentiation. Together with NKX2-2, initiates transcriptional activation of NEUROD1. Involved in neurogenesis.

Biological Context

Subcellular Location: Nucleus
Disease Association: Diarrhea 4, malabsorptive, congenital, with diabetes mellitus and combined pituitary hormone deficiency (DIAR4) : An autosomal recessive disease characterized by severe, life-threatening watery diarrhea associated with generalized malabsorption and a paucity of enteroendocrine cells. In addition to malabsorptive diarrhea, most patients develop insulin-dependent diabetes mellitus in the neonatal period or early childhood, and manifest short stature and delayed puberty. Pituitary gland hypoplasia with multiple pituitary hormone deficiencies and proximal renal tubulopathy have also been observed. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Neurogenin-3 (NEUROG3) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 1-214aa, with N-terminal 10xHis-tagged and C-terminal Myc-tagged tag, molecular weight 30.6kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

Is a transcriptional regulator involved in the control of enteroendocrine cell differentiation (PubMed:21378176). Together with NKX2-2, initiates transcriptional activation of NEUROD1 (PubMed:16855267, PubMed:21378176). Involved in neurogenesis. Also required for the specification of a common precursor of the 4 pancreatic endocrine cell types (By similarity)

Subcellular Location

Nucleus

Disease Association

Diarrhea 4, malabsorptive, congenital, with diabetes mellitus and combined pituitary hormone deficiency (DIAR4) : An autosomal recessive disease characterized by severe, life-threatening watery diarrhea associated with generalized malabsorption and a paucity of enteroendocrine cells. In addition to malabsorptive diarrhea, most patients develop insulin-dependent diabetes mellitus in the neonatal period or early childhood, and manifest short stature and delayed puberty. Pituitary gland hypoplasia with multiple pituitary hormone deficiencies and proximal renal tubulopathy have also been observed. [The disease is caused by variants affecting the gene represented in this entry]

Subunit

Efficient DNA binding requires dimerization with another bHLH protein. Interacts with ATOH8

Gene: NEUROG3  |  Organism: Homo sapiens  |  Synonyms: Class A basic helix-loop-helix protein 7; Protein atonal homolog 5
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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