Recombinant Human Neuromedin-U receptor 2 (NMUR2) Protein, in vitro E.coli expression system, C-terminal 10xHis-tagged, 49.2kDa, purity >85% as determined by SDS-PAGE.

Recombinant Human Neuromedin-U receptor 2 (NMUR2) Protein

Recombinant Human Neuromedin-U receptor 2 (NMUR2) Protein — G protein-coupled receptor for the neuropeptides neuromedin-U (NMU) and neuromedin-S (NMS). Purity >85%.

SKU: BCRECP-00538TM Category:
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Product Specifications

Uniprot No.Q9GZQ4
Gene NamesNMUR2
PurityGreater than 85% as determined by SDS-PAGE.
Expression Systemin vitro E.coli expression system
Expression Region1-415aa
Tag InfoC-terminal 10xHis-tagged
Molecular weight49.2kDa
ActivityNot Test
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Function

G protein-coupled receptor for the neuropeptides neuromedin-U (NMU) and neuromedin-S (NMS). Functionally, is involved in regulation of feeding and energy balance. Additionally may modulates blood pressure and smooth muscle contraction.

Product Specifications

Recombinant Human Neuromedin-U receptor 2 (NMUR2) Protein is a recombinant protein, expressed in in vitro E.coli expression system, covering amino acids 1-415aa, with C-terminal 10xHis-tagged tag, molecular weight 49.2kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

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Protein Biology

Function

G protein-coupled receptor for the neuropeptides neuromedin-U (NMU) and neuromedin-S (NMS) (PubMed:10887190, PubMed:10894543, PubMed:35440625, PubMed:36575163). Functionally, is involved in regulation of feeding and energy balance (By similarity). Additionally may modulates blood pressure and smooth muscle contraction (By similarity). Mechanistically, upon ligand binding, couples to Galpha proteins, namely GNAQ/Gaq or GNA11/Ga11 and GNAI1/Gai subunits (PubMed:11010960, PubMed:15331768, PubMed:35440625, PubMed:36575163). GNAQ/Gaq or GNA11/Ga11 coupling leads to the activation of a phospholipase C (PLC), which hydrolyzes PIP2 (phosphatidylinositol 4,5-bisphosphate) into DAG (diacylglycerol) and IP3 (inositol trisphosphate), and subsequent intracellular calcium mobilization via IP3 receptors on the endoplasmic reticulum (PubMed:11010960, PubMed:15331768). GNAI1/Gai coupling inhibits forskolin-stimulated cAMP accumulation (PubMed:15331768)

Gene: NMUR2  |  Organism: Homo sapiens

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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