Recombinant Human Neuron-specific calcium-binding protein hippocalcin (HPCA), Homo sapiens (Human), E.coli, N-terminal 10xHis-tagged and C-terminal Myc-tagged, 29.7kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Neuron-specific calcium-binding protein hippocalcin (HPCA)

Recombinant Human Neuron-specific calcium-binding protein hippocalcin (HPCA) — Calcium-binding protein that may play a role in the regulation of voltage-dependent calcium channels. Purity >90%.

SKU: BCRECP-000853 Category:
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Product Specifications

Product SkuBCRECP-000853
Product DescriptionRecombinant Human Neuron-specific calcium-binding protein hippocalcin (HPCA) Protein is expressed from E.coli with N-terminal 10xHis-tagged and C-terminal Myc-tagged. It contains 2-193aa. [Accession | P84074].
Uniprot No.P84074
Gene NamesHPCA
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region2-193aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 10xHis-tagged and C-terminal Myc-tagged
Molecular weight29.7kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasOthers

Function

Calcium-binding protein that may play a role in the regulation of voltage-dependent calcium channels. May also play a role in cyclic-nucleotide-mediated signaling through the regulation of adenylate and guanylate cyclases.

Biological Context

Subcellular Location: Cytoplasm, cytosol; Membrane (Peripheral membrane protein)
Tissue Specificity: Brain specific
Disease Association: Dystonia 2, torsion, autosomal recessive (DYT2) : A form of torsion dystonia, a disease defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. 'Torsion' refers to the twisting nature of body movements, often affecting the trunk. DYT2 is a slowly progressive form that first affects distal limbs and later involves the neck, orofacial, and craniocervical regions. [The disease is caused by variants affecting the gene represented in this entry]

Product Specifications

Recombinant Human Neuron-specific calcium-binding protein hippocalcin (HPCA) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 2-193aa, with N-terminal 10xHis-tagged and C-terminal Myc-tagged tag, molecular weight 29.7kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

Related products

Protein Biology

Function

Calcium-binding protein that may play a role in the regulation of voltage-dependent calcium channels (PubMed:28398555). May also play a role in cyclic-nucleotide-mediated signaling through the regulation of adenylate and guanylate cyclases (By similarity)

Subcellular Location

Cytoplasm, cytosol; Membrane (Peripheral membrane protein)

Disease Association

Dystonia 2, torsion, autosomal recessive (DYT2) : A form of torsion dystonia, a disease defined by the presence of sustained involuntary muscle contractions, often leading to abnormal postures. 'Torsion' refers to the twisting nature of body movements, often affecting the trunk. DYT2 is a slowly progressive form that first affects distal limbs and later involves the neck, orofacial, and craniocervical regions. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Brain specific

Subunit

Oligomer; oligomerization is calcium-dependent (PubMed:28398555). May interact with the voltage-dependent P/Q- and N-type calcium channels CACNA1A and CACNA1B (PubMed:28398555)

Gene: HPCA  |  Organism: Homo sapiens  |  Synonyms: Calcium-binding protein BDR-2
Key Publications

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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