Recombinant Human Neuronal acetylcholine receptor subunit alpha-10 (CHRNA10), partial, Homo sapiens (Human), E.coli, N-terminal GST-tagged, 51.0kDa, purity >90% as determined by SDS-PAGE.

Recombinant Human Neuronal acetylcholine receptor subunit alpha-10 (CHRNA10), partial

Recombinant Human Neuronal acetylcholine receptor subunit alpha-10 (CHRNA10), partial — Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability. Purity >90%.

SKU: BCRECP-000365 Category:
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Product Specifications

Product SkuBCRECP-000365
Product DescriptionRecombinant Human Neuronal acetylcholine receptor subunit alpha-10 (CHRNA10) Protein is expressed from E.coli with N-terminal GST-tagged. It contains 25-240aa. [Accession | Q9GZZ6].
Uniprot No.Q9GZZ6
Gene NamesCHRNA10
PurityGreater than 90% as determined by SDS-PAGE.
Expression SystemE.coli
Expression Region25-240aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal GST-tagged
Molecular weight51.0kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasNeuroscience

Function

Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators (Probable).

Biological Context

Subcellular Location: Synaptic cell membrane (Multi-pass membrane protein); Cell membrane (Multi-pass membrane protein)
Tissue Specificity: Expressed in inner-ear tissue, tonsil, immortalized B-cells, cultured T-cells and peripheral blood lymphocytes

Product Specifications

Recombinant Human Neuronal acetylcholine receptor subunit alpha-10 (CHRNA10), partial is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 25-240aa, with N-terminal GST-tagged tag, molecular weight 51.0kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

Related products

Protein Biology

Function

Component of neuronal acetylcholine receptors (nAChRs) that function as pentameric, ligand-gated cation channels with high calcium permeability. nAChRs are excitatory neurotrasnmitter receptors formed by a collection of nAChR subunits. Each nAchR subunit confers differential attributes to channel properties, including activation, deactivation and desensitization kinetics, pH sensitivity, cation permeability, and binding to allosteric modulators (Probable). Forms heteropentamers with CHRNA9. Expressed in the inner ear, in sympathetic neurons and in other non-neuronal cells, such as skin keratinocytes and lymphocytes (PubMed:11752216, PubMed:15531379). nAChR formed by CHRNA9:CHRNA10 is involved in modulation of auditory stimuli. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, mediates synaptic transmission between efferent olivocochlear fibers and hair cells of the cochlea, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing (PubMed:11752216). This may protect against acoustic trauma. May also regulate keratinocyte adhesion (By similarity)

Subcellular Location

Synaptic cell membrane (Multi-pass membrane protein); Cell membrane (Multi-pass membrane protein)

Tissue Specificity

Expressed in inner-ear tissue, tonsil, immortalized B-cells, cultured T-cells and peripheral blood lymphocytes

Subunit

Forms homo- or heterooligomeric channels in conjunction with CHRNA10. The native outer hair cell receptor may be composed of CHRNA9:CHRNA10 heterooligomers (PubMed:11752216). Found in the stoichiometric form (CHRNA9)2:(CHRNA10)3 (By similarity)

Gene: CHRNA10  |  Organism: Homo sapiens  |  Synonyms: Nicotinic acetylcholine receptor subunit alpha-10
Key Publications

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Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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