Recombinant Human Neuropeptide Y receptor type 2 (NPY2R) Protein, Homo sapiens (Human), in vitro E.coli expression system, N-terminal 10xHis-tagged, 48.8kDa, purity >85% as determined by SDS-PAGE.

Recombinant Human Neuropeptide Y receptor type 2 (NPY2R) Protein

Recombinant Human Neuropeptide Y receptor type 2 (NPY2R) Protein — Receptor for neuropeptide Y (NPY) and peptide YY (PYY). Purity >85%.

SKU: BCRECP-00162TM Category:
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Product Specifications

Uniprot No.P49146
Gene NamesNPY2R
PurityGreater than 85% as determined by SDS-PAGE.
Expression Systemin vitro E.coli expression system
Expression Region1-381aa
SpeciesHomo sapiens (Human)
Tag InfoN-terminal 10xHis-tagged
Molecular weight48.8kDa
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Function

Receptor for neuropeptide Y (NPY) and peptide YY (PYY). Can also bind with lower affinity pancreatic polypeptide (PP/PPY) and [Leu-31, Pro-34]NPY, an analog of NPY modified at residues 31 and 34 of the mature form. NPY or PYY binding induces adenylate cyclase-inhibiting G protein-coupled receptor signaling, resulting in inhibition of cAMP production.

Biological Context

Subcellular Location: Cell membrane (Multi-pass membrane protein)
Tissue Specificity: High levels in amygdala, corpus callosum, hippocampus and subthalamic nucleus. Also detectable in caudate nucleus, hypothalamus and substantia nigra

Product Specifications

Recombinant Human Neuropeptide Y receptor type 2 (NPY2R) Protein is a recombinant protein from Homo sapiens (Human), expressed in in vitro E.coli expression system, covering amino acids 1-381aa, with N-terminal 10xHis-tagged tag, molecular weight 48.8kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Not implied unless activity data are explicitly listed on this product page, the datasheet, or the CoA.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

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Protein Biology

Function

Receptor for neuropeptide Y (NPY) and peptide YY (PYY) (PubMed:7592910, PubMed:7559383, PubMed:35507650, PubMed:36525977, PubMed:38882210). Can also bind with lower affinity pancreatic polypeptide (PP/PPY) and [Leu-31, Pro-34]NPY, an analog of NPY modified at residues 31 and 34 of the mature form. NPY or PYY binding induces adenylate cyclase-inhibiting G protein-coupled receptor signaling, resulting in inhibition of cAMP production (PubMed:7592910, PubMed:7559383, PubMed:35507650, PubMed:38882210). Receptor activation by ligands also leads to an increase of intracellular Ca(2+) levels (PubMed:7559383, PubMed:7592910). Involved in the regulation of colonic antisecretory tone, and colonic contractility (By similarity). As receptor for peptide PYY(3-36) in the arcuate nucleus of the hypothalamus, it is involved in the down-regulation of appetite and food intake (By similarity)

Subcellular Location

Cell membrane (Multi-pass membrane protein)

Tissue Specificity

High levels in amygdala, corpus callosum, hippocampus and subthalamic nucleus. Also detectable in caudate nucleus, hypothalamus and substantia nigra

Subunit

Interacts with GNAI1; the interaction stabilizes the receptor in the high affinity state for NPY (PubMed:35507650, PubMed:36525977). Upon activation by NPY or PYY, interacts with ARRB2 (PubMed:36525977)

Gene: NPY2R  |  Organism: Homo sapiens  |  Synonyms: NPY-Y2 receptor
Key Publications

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Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

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Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

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Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

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Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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