Function
(Microbial infection) Inhibited reversibly by S.aureus serine protease inhibitors Eap, EapH1 and EapH2, impairing microbicidal activity in neutrophils.
Biological Context
Subcellular Location: Cytoplasmic vesicle, phagosome; Lysosome; Cytolytic granule; Nucleus
Tissue Specificity: Bone marrow cells. Neutrophil
Disease Association: Cyclic haematopoiesis (CH) : Autosomal dominant disease in which blood-cell production from the bone marrow oscillates with 21-day periodicity. Circulating neutrophils vary between almost normal numbers and zero. During intervals of neutropenia, affected individuals are at risk for opportunistic infection. Monocytes, platelets, lymphocytes and reticulocytes also cycle with the same frequency. [The disease is caused by variants affecting the gene represented in this entry] | Neutropenia, severe congenital 1, autosomal dominant (SCN1) : A disorder of hematopoiesis characterized by maturation arrest of granulopoiesis at the level of promyelocytes with peripheral blood absolute neutrophil counts below 0.5 x 10(9)/l and early onset of severe bacterial infections. [The disease is caused by variants affecting the gene represented in this entry]
Product Specifications
Recombinant Human Neutrophil elastase (ELANE) is a recombinant protein from Homo sapiens (Human), expressed in E.coli, covering amino acids 30-267aa, with N-terminal GST-tagged tag, molecular weight 52.6kDa, purity Greater than 90% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.
