Recombinant Human O-phosphoseryl-tRNA (Sec) selenium transferase (SEPSECS), Homo sapiens (Human), Yeast, C-terminal 6xHis-tagged, 56.5kDa, purity >85% as determined by SDS-PAGE.
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Recombinant Human O-phosphoseryl-tRNA (Sec) selenium transferase (SEPSECS)

Recombinant Human O-phosphoseryl-tRNA (Sec) selenium transferase (SEPSECS) — recombinant protein from Homo sapiens (Human), expressed in Yeast. Purity >85%.

SKU: BCRECP-001611 Categories: ,
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Product Specifications

Product SkuBCRECP-001611
Product DescriptionRecombinant Human O-phosphoseryl-tRNA (Sec) selenium transferase (SEPSECS) Protein is expressed from Yeast with C-terminal 6xHis-tagged. It contains 1-501aa. [Accession | Q9HD40].
Uniprot No.Q9HD40
Gene NamesSEPSECS
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemYeast
Expression Region1-501aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal 6xHis-tagged
Molecular weight56.5kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasEpigenetics and Nuclear Signaling

Function

Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.

Biological Context

Subcellular Location: Cytoplasm
Tissue Specificity: Primarily expressed in liver, pancreas, kidney and lung. Overexpressed in PHA-stimulated T-cells
Disease Association: Pontocerebellar hypoplasia 2D (PCH2D) : A disorder characterized by postnatal onset of progressive atrophy of the cerebrum and cerebellum, microcephaly, profound intellectual disability, spasticity, and variable seizures. [The disease is caused by variants affecting the gene represented in this entry]
Pathway: Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; selenocysteinyl-tRNA(Sec) from L-seryl-tRNA(Sec) (archaeal/eukaryal route): step 2/2

Product Specifications

Recombinant Human O-phosphoseryl-tRNA (Sec) selenium transferase (SEPSECS) is a recombinant protein from Homo sapiens (Human), expressed in Yeast, covering amino acids 1-501aa, with C-terminal 6xHis-tagged tag, molecular weight 56.5kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

Recommended applications depend on the target, product format, and product-specific validation data. Refer to the product datasheet or Certificate of Analysis (CoA), or contact BioCrest Sci for application guidance.

Biological Activity: Please contact us to obtain bioactivity data.

Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.

Shipping & Lead Time: Availability, shipping conditions, and estimated lead time are confirmed in the formal quotation or order confirmation based on the product format, destination, and order requirements.

Related products

Protein Biology

Function

Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis

Subcellular Location

Cytoplasm

Disease Association

Pontocerebellar hypoplasia 2D (PCH2D) : A disorder characterized by postnatal onset of progressive atrophy of the cerebrum and cerebellum, microcephaly, profound intellectual disability, spasticity, and variable seizures. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Primarily expressed in liver, pancreas, kidney and lung. Overexpressed in PHA-stimulated T-cells

Subunit

Homotetramer formed by a catalytic dimer and a non-catalytic dimer serving as a binding platform that orients tRNASec for catalysis (PubMed:19608919). Each tetramer binds the CCA ends of two tRNAs which point to the active sites of the catalytic dimer (PubMed:19608919). Component of a complex composed of SEPHS1, SEPHS2, SEPSECS and TRNAU1AP (PubMed:16508009, PubMed:28414460)

Pathway

Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; selenocysteinyl-tRNA(Sec) from L-seryl-tRNA(Sec) (archaeal/eukaryal route): step 2/2

Gene: SEPSECS  |  Organism: Homo sapiens  |  Synonyms: Liver-pancreas antigen; SLA-p35; SLA/LP autoantigen; Selenocysteine synthase; Selenocysteinyl-tRNA(Sec) synthase; Sep-tRNA:Sec-tRNA synthase; Soluble liver antigen; UGA suppressor tRNA-associated protein; tRNA(Ser/Sec)-associated antigenic protein
Key Publications

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Frequently Asked Questions

How do I order or inquire about this product?

Submit the Online Inquiry form with your required quantity and specifications, or email sales@biocrestsci.com. Available sizes, pricing, stock status, documentation, and estimated lead time are confirmed in the formal quotation.

What is the shipping and delivery time?

Availability, dispatch timing, shipping conditions, and delivery estimates depend on the product format, destination, and order requirements. These details are confirmed in the formal quotation or order confirmation.

How should this product be stored?

Follow the storage and handling instructions in the product-specific datasheet and Certificate of Analysis (CoA). Requirements may vary by product form and formulation; contact BioCrest Sci if product-specific guidance is needed.

What quality controls are performed on your products?

Quality-control data such as identity, purity, endotoxin level, or biological activity are provided only when specified on this product page, the datasheet, or Certificate of Analysis (CoA). Biological activity is not implied unless explicitly stated.

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