Recombinant Human O-phosphoseryl-tRNA (Sec) selenium transferase (SEPSECS), Homo sapiens (Human), Yeast, C-terminal 6xHis-tagged, 56.5kDa, purity >85% as determined by SDS-PAGE.
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Recombinant Human O-phosphoseryl-tRNA (Sec) selenium transferase (SEPSECS)

Recombinant Human O-phosphoseryl-tRNA (Sec) selenium transferase (SEPSECS) — recombinant protein from Homo sapiens (Human), expressed in Yeast. Purity >85%.

SKU: BCRECP-001611 Categories: ,
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Product Specifications

Product SkuBCRECP-001611
Product DescriptionRecombinant Human O-phosphoseryl-tRNA (Sec) selenium transferase (SEPSECS) Protein is expressed from Yeast with C-terminal 6xHis-tagged. It contains 1-501aa. [Accession | Q9HD40].
Uniprot No.Q9HD40
Gene NamesSEPSECS
PurityGreater than 85% as determined by SDS-PAGE.
Expression SystemYeast
Expression Region1-501aa
SpeciesHomo sapiens (Human)
Tag InfoC-terminal 6xHis-tagged
Molecular weight56.5kDa
ActivityPlease contact us to obtain bioactivity data.
BufferIf the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
StorageStore at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Research AreasEpigenetics and Nuclear Signaling

Function

Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.

Biological Context

Subcellular Location: Cytoplasm
Tissue Specificity: Primarily expressed in liver, pancreas, kidney and lung. Overexpressed in PHA-stimulated T-cells
Disease Association: Pontocerebellar hypoplasia 2D (PCH2D) : A disorder characterized by postnatal onset of progressive atrophy of the cerebrum and cerebellum, microcephaly, profound intellectual disability, spasticity, and variable seizures. [The disease is caused by variants affecting the gene represented in this entry]
Pathway: Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; selenocysteinyl-tRNA(Sec) from L-seryl-tRNA(Sec) (archaeal/eukaryal route): step 2/2

Product Specifications

Recombinant Human O-phosphoseryl-tRNA (Sec) selenium transferase (SEPSECS) is a recombinant protein from Homo sapiens (Human), expressed in Yeast, covering amino acids 1-501aa, with C-terminal 6xHis-tagged tag, molecular weight 56.5kDa, purity Greater than 85% as determined by SDS-PAGE.. Suitable for ELISA and Western Blot applications.

SDS-PAGE: Single band at expected molecular weight confirming purity.

ELISA: Suitable as coating antigen or detection standard.

Western Blot: Compatible with standard Western Blot protocols.

Protein Interaction: Validated for SPR (Surface Plasmon Resonance) and BLI (Bio-Layer Interferometry) studies.

Shipping: Shipped at ambient temperature. Lyophilized protein is stable during transit.

Storage: Store lyophilized protein at -20°C to -80°C. Reconstituted protein should be aliquoted and stored at -80°C. Avoid repeated freeze-thaw cycles.

Shelf Life: 12 months from date of receipt when stored as recommended.

Shipping Time: Orders placed before 2 PM EST ship same day. International orders typically deliver within 5-10 business days.

Related products

Protein Biology

Function

Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis

Subcellular Location

Cytoplasm

Disease Association

Pontocerebellar hypoplasia 2D (PCH2D) : A disorder characterized by postnatal onset of progressive atrophy of the cerebrum and cerebellum, microcephaly, profound intellectual disability, spasticity, and variable seizures. [The disease is caused by variants affecting the gene represented in this entry]

Tissue Specificity

Primarily expressed in liver, pancreas, kidney and lung. Overexpressed in PHA-stimulated T-cells

Subunit

Homotetramer formed by a catalytic dimer and a non-catalytic dimer serving as a binding platform that orients tRNASec for catalysis (PubMed:19608919). Each tetramer binds the CCA ends of two tRNAs which point to the active sites of the catalytic dimer (PubMed:19608919). Component of a complex composed of SEPHS1, SEPHS2, SEPSECS and TRNAU1AP (PubMed:16508009, PubMed:28414460)

Pathway

Aminoacyl-tRNA biosynthesis; selenocysteinyl-tRNA(Sec) biosynthesis; selenocysteinyl-tRNA(Sec) from L-seryl-tRNA(Sec) (archaeal/eukaryal route): step 2/2

Gene: SEPSECS  |  Organism: Homo sapiens  |  Synonyms: Liver-pancreas antigen; SLA-p35; SLA/LP autoantigen; Selenocysteine synthase; Selenocysteinyl-tRNA(Sec) synthase; Sep-tRNA:Sec-tRNA synthase; Soluble liver antigen; UGA suppressor tRNA-associated protein; tRNA(Ser/Sec)-associated antigenic protein
Key Publications

Frequently Asked Questions

How do I order or inquire about this product?

Fill out the Online Inquiry form with your required quantity and specifications. You can also email sales@biocrestsci.com. Our team typically responds within 4 business hours with a quote and availability confirmation.

What is the shipping and delivery time?

Orders placed before 2 PM EST ship the same day. Domestic (US) delivery typically takes 2-3 business days. International orders deliver within 5-10 business days. All products are shipped at ambient temperature with appropriate packaging to ensure stability.

How should I store this recombinant protein?

Lyophilized proteins should be stored at -20°C to -80°C upon receipt. After reconstitution, aliquot and store at -80°C. Avoid repeated freeze-thaw cycles. Shelf life is 12 months from date of receipt when stored as recommended.

What quality controls are performed on your products?

Each product undergoes SDS-PAGE purity analysis (typically >85-95%), endotoxin testing, and bioactivity validation. Products are validated for ELISA, Western Blot, and SPR/BLI applications as specified on this product page. A Certificate of Analysis (CoA) is available upon request.

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